RASSF1 anticorps (Internal Region)
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- Antigène Voir toutes RASSF1 Anticorps
- RASSF1 (Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1))
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Épitope
- Internal Region
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp RASSF1 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Specificité
- RASSF1 Antibody detects endogenous levels of total RASSF1.
- Homologie
- Pig,Bovine,Horse,Sheep,Rabbit,Dog
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human RASSF1, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product RASSF1 Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- RASSF1 (Ras Association (RalGDS/AF-6) Domain Family Member 1 (RASSF1))
- Autre désignation
- RASSF1 (RASSF1 Produits)
- Synonymes
- anticorps RASSF1, anticorps zgc:92505, anticorps wu:fc17f02, anticorps zgc:112224, anticorps 123F2, anticorps NORE2A, anticorps RASSF1A, anticorps RDA32, anticorps REH3P21, anticorps AA536941, anticorps AU044980, anticorps Rassf1A, anticorps Rassf1B, anticorps Rassf1C, anticorps NPR2-like, GATOR1 complex subunit, anticorps Ras association (RalGDS/AF-6) domain family 1, anticorps Ras association domain family member 1, anticorps putative rassf1, anticorps Ras association domain family member 1 L homeolog, anticorps Ras association (RalGDS/AF-6) domain family member 1, anticorps NPRL2, anticorps rassf1, anticorps RASSF1, anticorps Smp_157340, anticorps rassf1.L, anticorps Rassf1
- Sujet
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Description: Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF10 stimulation. Isoform A interacts with CDC20, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.
Gene: RASSF1
- Poids moléculaire
- 39kDa
- ID gène
- 11186
- UniProt
- Q9NS23
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