RBBP6 anticorps (Internal Region)
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- Antigène Voir toutes RBBP6 Anticorps
- RBBP6 (Retinoblastoma Binding Protein 6 (RBBP6))
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Épitope
- Internal Region
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp RBBP6 est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Specificité
- RBBP6 Antibody detects endogenous levels of total RBBP6.
- Homologie
- Pig,Bovine,Sheep,Rabbit,Dog,Chicken
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human RBBP6, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product RBBP6 Anticorps primaire
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- Indications d'application
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- RBBP6 (Retinoblastoma Binding Protein 6 (RBBP6))
- Autre désignation
- RBBP6 (RBBP6 Produits)
- Synonymes
- anticorps MY038, anticorps P2P-R, anticorps PACT, anticorps RBQ-1, anticorps SNAMA, anticorps 4933422O15Rik, anticorps AI316869, anticorps BB233631, anticorps C030034J04Rik, anticorps C77662, anticorps rbbp6, anticorps MGC75882, anticorps RBBP6, anticorps im:7158869, anticorps rbbp6l, anticorps RB binding protein 6, ubiquitin ligase, anticorps retinoblastoma binding protein 6, ubiquitin ligase, anticorps retinoblastoma binding protein 6, anticorps RBBP6, anticorps Rbbp6, anticorps rbbp6
- Sujet
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Description: E3 ubiquitin-protein ligase which promotes ubiquitination of YBX1, leading to its degradation by the proteasome (PubMed:18851979). May play a role as a scaffold protein to promote the assembly of the p53/TP53-MDM2 complex, resulting in increase of MDM2-mediated ubiquitination and degradation of p53/TP53, may function as negative regulator of p53/TP53, leading to both apoptosis and cell growth (By similarity). Regulates DNA-replication and the stability of chromosomal common fragile sites (CFSs) in a ZBTB38- and MCM10-dependent manner. Controls ZBTB38 protein stability and abundance via ubiquitination and proteasomal degradation, and ZBTB38 in turn negatively regulates the expression of MCM10 which plays an important role in DNA-replication (PubMed:24726359).
Gene: RBBP6
- Poids moléculaire
- 202 kDa
- ID gène
- 5930
- UniProt
- Q7Z6E9
- Pathways
- Regulatory RNA Pathways
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