REST anticorps (C-Term)
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- Antigène Voir toutes REST Anticorps
- REST (RE1-Silencing Transcription Factor (REST))
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Épitope
- C-Term
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Reactivité
- Humain, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp REST est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificité
- REST Antibody detects endogenous levels of total REST.
- Homologie
- Horse,Rabbit,Dog
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human REST, corresponding to a region within C-terminal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product REST Anticorps primaire
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- Indications d'application
- WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- REST (RE1-Silencing Transcription Factor (REST))
- Autre désignation
- REST (REST Produits)
- Synonymes
- anticorps NRSF, anticorps XBR, anticorps 2610008J04Rik, anticorps AA407358, anticorps xbr, anticorps nrsf, anticorps rest, anticorps resta, anticorps REST, anticorps RE1 silencing transcription factor, anticorps RE1-silencing transcription factor, anticorps RE1-silencing transcription factor S homeolog, anticorps REST, anticorps Rest, anticorps rest.S, anticorps rest, anticorps LOC615792
- Sujet
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Description: Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes. Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression.
Gene: REST
- Poids moléculaire
- 121 kDa
- ID gène
- 5978
- UniProt
- Q13127
- Pathways
- Negative Regulation of Hormone Secretion, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Chromatin Binding, Positive Regulation of Endopeptidase Activity
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