RNF2 anticorps (Internal Region)
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- Antigène Voir toutes RNF2 Anticorps
- RNF2 (Ring Finger Protein 2 (RNF2))
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Épitope
- Internal Region
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp RNF2 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Specificité
- RNF2 Antibody detects endogenous levels of total RNF2.
- Homologie
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human RNF2, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product RNF2 Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- RNF2 (Ring Finger Protein 2 (RNF2))
- Autre désignation
- RNF2 (RNF2 Produits)
- Synonymes
- anticorps BAP-1, anticorps BAP1, anticorps DING, anticorps HIPI3, anticorps RING1B, anticorps RING2, anticorps AI326319, anticorps AI450156, anticorps AU019207, anticorps Ring1B, anticorps dinG, anticorps fa19h05, anticorps ring1b, anticorps wu:fa19h05, anticorps wz4556, anticorps bap-1, anticorps bap1, anticorps ding, anticorps hipi3, anticorps ring2, anticorps ring finger protein 2, anticorps ring finger protein 2 L homeolog, anticorps RNF2, anticorps Rnf2, anticorps rnf2, anticorps rnf2.L
- Sujet
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Description: E3 ubiquitin-protein ligase that mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), thereby playing a central role in histone code and gene regulation (PubMed:15386022, PubMed:16359901, PubMed:25519132, PubMed:21772249, PubMed:25355358, PubMed:26151332). H2AK119Ub gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. May be involved in the initiation of both imprinted and random X inactivation (By similarity). Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development (PubMed:16359901, PubMed:26151332). PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility (PubMed:26151332). E3 ubiquitin-protein ligase activity is enhanced by BMI1/PCGF4 (PubMed:21772249). Acts as the main E3 ubiquitin ligase on histone H2A of the PRC1 complex, while RING1 may rather act as a modulator of RNF2/RING2 activity (Probable). Association with the chromosomal DNA is cell-cycle dependent. In resting B- and T-lymphocytes, interaction with AURKB leads to block its activity, thereby maintaining transcription in resting lymphocytes (By similarity).
Gene: RNF2
- Poids moléculaire
- 37kDa
- ID gène
- 6045
- UniProt
- Q99496
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