RNF41 anticorps (Internal Region)

N° du produit ABIN6264789

Détail du produit anti-RNF41 anticorps

Antigène: RNF41 (Ring Finger Protein 41 (RNF41))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp RNF41 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: RNF41 Antibody detects endogenous levels of total RNF41.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human RNF41, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur RNF41

Antigène: RNF41 (Ring Finger Protein 41 (RNF41))

Autre désignation: RNF41 (RNF41 Produits)

Synonymes: anticorps FLRF, anticorps NRDP1, anticorps 2210404G21Rik, anticorps 4930511A05Rik, anticorps 4933415P08Rik, anticorps D10Ertd722e, anticorps Nrdp1, anticorps wu:fi13f07, anticorps wu:fi25b06, anticorps zgc:55389, anticorps flrf, anticorps ring finger protein 41, anticorps ring finger protein 41 S homeolog, anticorps ring finger protein 41, E3 ubiquitin protein ligase, anticorps RNF41, anticorps Rnf41, anticorps rnf41, anticorps rnf41.S

Sujet:

Description: Acts as E3 ubiquitin-protein ligase and regulates the degradation of target proteins. Polyubiquitinates MYD88. Negatively regulates MYD88-dependent production of proinflammatory cytokines. Can promote TRIF-dependent production of type I interferon and inhibits infection with vesicular stomatitis virus (By similarity). Promotes also activation of TBK1 and IRF3. Involved in the ubiquitination of erythropoietin (EPO) and interleukin-3 (IL-3) receptors. Thus, through maintaining basal levels of cytokine receptors, RNF41 is involved in the control of hematopoietic progenitor cell differentiation into myeloerythroid lineages (By similarity). Contributes to the maintenance of steady-state ERBB3 levels by mediating its growth factor-independent degradation. Involved in the degradation of the inhibitor of apoptosis BIRC6 and thus is an important regulator of cell death by promoting apoptosis. Acts also as a PRKN modifier that accelerates its degradation, resulting in a reduction of PRKN activity, influencing the balance of intracellular redox state. The RNF41-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control (PubMed:24949970).

Gene: RNF41

Poids moléculaire: 36 kDa

ID gène: 10193

UniProt: Q9H4P4

Pathways: SARS-CoV-2 Protein Interactome