ROS1 anticorps (C-Term)

N° du produit ABIN6264807

Détail du produit anti-ROS1 anticorps

Antigène: ROS1 (C-Ros Oncogene 1 , Receptor tyrosine Kinase (ROS1))

Épitope: C-Term

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ROS1 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: ROS Antibody detects endogenous levels of total ROS.

Homologie: Pig,Horse,Sheep

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human ROS, corresponding to a region within C-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur ROS1

Antigène: ROS1 (C-Ros Oncogene 1 , Receptor tyrosine Kinase (ROS1))

Autre désignation: ROS1 (ROS1 Produits)

Synonymes: anticorps MCF3, anticorps ROS, anticorps c-ros-1, anticorps ROS1C, anticorps Ros-1, anticorps c-ros, anticorps ROS proto-oncogene 1, receptor tyrosine kinase, anticorps ROS proto-oncogene 1 , receptor tyrosine kinase, anticorps Ros1 proto-oncogene, anticorps ROS1, anticorps Ros1

Sujet:

Description: Orphan receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including the PI3 kinase-mTOR signaling pathway. Mediates the phosphorylation of PTPN11, an activator of this pathway. May also phosphorylate and activate the transcription factor STAT3 to control anchorage-independent cell growth. Mediates the phosphorylation and the activation of VAV3, a guanine nucleotide exchange factor regulating cell morphology. May activate other downstream signaling proteins including AKT1, MAPK1, MAPK3, IRS1 and PLCG2.

Gene: ROS1

Poids moléculaire: 263kDa

ID gène: 6098

UniProt: P08922

Pathways: Signalisation RTK