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SENP6 anticorps (Internal Region)

SENP6 Reactivité: Humain, Souris ELISA, IHC, WB Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6264987
  • Antigène Voir toutes SENP6 Anticorps
    SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))
    Épitope
    • 13
    • 8
    • 7
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 47
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 43
    • 2
    • 2
    Lapin
    Clonalité
    • 45
    • 2
    Polyclonal
    Conjugué
    • 22
    • 5
    • 4
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SENP6 est non-conjugé
    Application
    • 31
    • 25
    • 19
    • 8
    • 5
    • 4
    • 1
    ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
    Specificité
    SENP6 Antibody detects endogenous levels of total SENP6.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human SENP6, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product SENP6 Anticorps primaire
  • Indications d'application
    IHC 1:50-1:200, WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    SENP6 (SUMO1/sentrin Specific Protease 6 (SENP6))
    Autre désignation
    SENP6 (SENP6 Produits)
    Synonymes
    anticorps SSP1, anticorps SUSP1, anticorps 2810017C20Rik, anticorps E130319N12Rik, anticorps Susp1, anticorps mKIAA0797, anticorps fc83h02, anticorps im:7148342, anticorps wu:fc83h02, anticorps zgc:171230, anticorps SUMO1/sentrin specific peptidase 6, anticorps SUMO/sentrin specific peptidase 6, anticorps SUMO1/sentrin specific peptidase 6a, anticorps SENP6, anticorps Senp6, anticorps senp6a
    Sujet

    Description: Protease that deconjugates SUMO1, SUMO2 and SUMO3 from targeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 and SUMO3 precursors. Deconjugates SUMO1 from RXRA, leading to transcriptional activation. Involved in chromosome alignment and spindle assembly, by regulating the kinetochore CENPH-CENPI-CENPK complex. Desumoylates PML and CENPI, protecting them from degradation by the ubiquitin ligase RNF4, which targets polysumoylated proteins for proteasomal degradation. Desumoylates also RPA1, thus preventing recruitment of RAD51 to the DNA damage foci to initiate DNA repair through homologous recombination.

    Gene: SENP6

    Poids moléculaire
    126kDa
    ID gène
    26054
    UniProt
    Q9GZR1
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