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SIAH2 anticorps (C-Term)

SIAH2 Reactivité: Humain, Souris, Rat WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6265080
  • Antigène Voir toutes SIAH2 Anticorps
    SIAH2 (Siah E3 Ubiquitin Protein Ligase 2 (SIAH2))
    Épitope
    • 7
    • 6
    • 6
    • 6
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 36
    • 15
    • 14
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 34
    • 2
    Lapin
    Clonalité
    • 34
    • 2
    Polyclonal
    Conjugué
    • 16
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SIAH2 est non-conjugé
    Application
    • 23
    • 20
    • 19
    • 13
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    SIAH2 Antibody detects endogenous levels of total SIAH2.
    Homologie
    Pig,Bovine,Sheep,Rabbit,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human SIAH2, corresponding to a region within C-terminal amino acids.
    Isotype
    IgG
  • Indications d'application
    WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    SIAH2 (Siah E3 Ubiquitin Protein Ligase 2 (SIAH2))
    Autre désignation
    SIAH2 (SIAH2 Produits)
    Synonymes
    anticorps hSiah2, anticorps Xsiah-2, anticorps siah2-A, anticorps xsiah2, anticorps AA415433, anticorps Sinh2, anticorps siah E3 ubiquitin protein ligase 2, anticorps siah E3 ubiquitin protein ligase 2 L homeolog, anticorps seven in absentia 2, anticorps SIAH2, anticorps siah2.L, anticorps Siah2
    Sujet

    Description: Essential component of a MLL/SET1 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3 (H3K4). Functions as a transcriptional regulator. Binds to the TERT promoter and represses telomerase expression. Plays a role in TGFB1-mediated inhibition of cell-proliferation, possibly regulating SMAD3 transcriptional activity. Represses JUND-mediated transcriptional activation on AP1 sites, as well as that mediated by NFKB subunit RELA. Positively regulates HOXC8 and HOXC6 gene expression. May be involved in normal hematopoiesis through the activation of HOXA9 expression (By similarity). May be involved in DNA repair.

    Gene: MEN1

    Poids moléculaire
    36 kDa
    ID gène
    6478
    UniProt
    O43255
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