SPOP-B anticorps (Internal Region)
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- Antigène Voir toutes SPOP-B Anticorps
- SPOP-B (Speckle-Type POZ Protein (SPOP-B))
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Épitope
- Internal Region
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp SPOP-B est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
- Specificité
- SPOP Antibody detects endogenous levels of total SPOP.
- Homologie
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human SPOP, corresponding to a region within the internal amino acids.
- Isotype
- IgG
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- Indications d'application
- WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- SPOP-B (Speckle-Type POZ Protein (SPOP-B))
- Autre désignation
- SPOP (SPOP-B Produits)
- Synonymes
- anticorps BTBD32, anticorps TEF2, anticorps AI315626, anticorps Pcif1, anticorps zgc:64140, anticorps spop, anticorps tef2, anticorps speckle type BTB/POZ protein, anticorps speckle-type POZ protein, anticorps speckle type POZ protein S homeolog, anticorps SPOP, anticorps Spop, anticorps spop, anticorps spop.S
- Sujet
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Description: Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates the ubiquitination of target proteins, leading most often to their proteasomal degradation. In complex with CUL3, involved in ubiquitination and proteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3. In complex with CUL3, involved in ubiquitination of H2AFY and BMI1, this does not lead to their proteasomal degradation. Inhibits transcriptional activation of PDX1/IPF1 targets, such as insulin, by promoting PDX1/IPF1 degradation. The cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containing homodimeric SPOP has higher ubiquitin ligase activity than the complex that contains the heterodimer formed by SPOP and SPOPL.
Gene: SPOP
- Poids moléculaire
- 42 kDa
- ID gène
- 8405
- UniProt
- O43791
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