SRPK2 anticorps

N° du produit ABIN6265291

Détail du produit anti-SRPK2 anticorps

Antigène: SRPK2 (SFRS Protein Kinase 2 (SRPK2))

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SRPK2 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Specificité: SRPK2 Antibody detects endogenous levels of total SRPK2

Réactivité croisée: Humain, Souris, Rat (Rattus)

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human SRPK2

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000 IHC 1:200

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Détails sur SRPK2

Antigène: SRPK2 (SFRS Protein Kinase 2 (SRPK2))

Autre désignation: SRPK2 (SRPK2 Produits)

Synonymes: anticorps SFRSK2, anticorps AW226533, anticorps AW492537, anticorps AW547358, anticorps Wbp6, anticorps mSRPK2, anticorps sfrsk2, anticorps srpk2, anticorps srpk2-b, anticorps srpk2b, anticorps SRSF protein kinase 2, anticorps serine/arginine-rich protein specific kinase 2, anticorps SRSF protein kinase 2 L homeolog, anticorps SRPK2, anticorps Srpk2, anticorps srpk2, anticorps srpk2.L

Sujet:

Description: Serine/arginine-rich protein-specific kinase which specifically phosphorylates its substrates at serine residues located in regions rich in arginine/serine dipeptides, known as RS domains and is involved in the phosphorylation of SR splicing factors and the regulation of splicing. Promotes neuronal apoptosis by up-regulating cyclin-D1 (CCND1) expression. This is done by the phosphorylation of SRSF2, leading to the suppression of p53/TP53 phosphorylation thereby relieving the repressive effect of p53/TP53 on cyclin-D1 (CCND1) expression. Phosphorylates ACIN1, and redistributes it from the nuclear speckles to the nucleoplasm, resulting in cyclin A1 but not cyclin A2 up-regulation. Plays an essential role in spliceosomal B complex formation via the phosphorylation of DDX23/PRP28. Can mediate hepatitis B virus (HBV) core protein phosphorylation. Plays a negative role in the regulation of HBV replication through a mechanism not involving the phosphorylation of the core protein but by reducing the packaging efficiency of the pregenomic RNA (pgRNA) without affecting the formation of the viral core particles.

Gene: SRPK2

Poids moléculaire: 78 kDa

ID gène: 6733

UniProt: P78362

Pathways: Ribonucleoprotein Complex Subunit Organization