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SUMO1 anticorps (N-Term)

SUMO1 Reactivité: Humain, Rat, Souris WB, IF, IHC, ELISA, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6265373
  • Antigène Voir toutes SUMO1 Anticorps
    SUMO1 (Small Ubiquitin Related Modifier Protein 1 (SUMO1))
    Épitope
    • 15
    • 15
    • 10
    • 8
    • 8
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 94
    • 77
    • 72
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Rat, Souris
    Hôte
    • 98
    • 31
    • 3
    • 1
    • 1
    Lapin
    Clonalité
    • 90
    • 45
    Polyclonal
    Conjugué
    • 68
    • 10
    • 7
    • 6
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp SUMO1 est non-conjugé
    Application
    • 108
    • 46
    • 45
    • 36
    • 33
    • 27
    • 26
    • 24
    • 15
    • 9
    • 8
    • 7
    • 6
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC)
    Specificité
    Sumo1 Antibody detects endogenous levels of total Sumo1.
    Homologie
    Pig,Zebrafish,Bovine,Horse,Dog,Chicken
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human Sumo1, corresponding to a region within N-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product SUMO1 Anticorps primaire
  • Indications d'application
    WB: 1:500-1:3000, IHC: 1:50-1:200, IF/ICC: 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    SUMO1 (Small Ubiquitin Related Modifier Protein 1 (SUMO1))
    Autre désignation
    SUMO1 (SUMO1 Produits)
    Sujet

    Description: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1, this modulates the gating characteristics of KCNB1 (PubMed:19223394). Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. Covalently attached to ZFHX3 (PubMed:24651376).

    Gene: SUMO1

    Poids moléculaire
    12kDa
    ID gène
    7341
    UniProt
    P63165
    Pathways
    M Phase, Positive Regulation of Endopeptidase Activity, Protein targeting to Nucleus, Ubiquitin Proteasome Pathway
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