TERT anticorps (Internal Region)
-
- Antigène Voir toutes TERT Anticorps
- TERT (Telomerase Reverse Transcriptase (TERT))
-
Épitope
- Internal Region
-
Reactivité
- Humain
-
Hôte
- Lapin
-
Clonalité
- Polyclonal
-
Conjugué
- Cet anticorp TERT est non-conjugé
-
Application
- Western Blotting (WB), ELISA
- Specificité
- TERT Antibody detects endogenous levels of total TERT.
- Homologie
- Pig,Dog
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human TERT, corresponding to a region within the internal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product TERT Anticorps primaire
-
-
- Indications d'application
- WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
-
-
hTERT promotes the invasion of gastric cancer cells by enhancing FOXO3a ubiquitination and subsequent ITGB1 upregulation." dans: Gut, Vol. 66, Issue 1, pp. 31-42, (2017) (PubMed).
: "
-
hTERT promotes the invasion of gastric cancer cells by enhancing FOXO3a ubiquitination and subsequent ITGB1 upregulation." dans: Gut, Vol. 66, Issue 1, pp. 31-42, (2017) (PubMed).
-
- Antigène
- TERT (Telomerase Reverse Transcriptase (TERT))
- Autre désignation
- TERT (TERT Produits)
- Synonymes
- anticorps CMM9, anticorps DKCA2, anticorps DKCB4, anticorps EST2, anticorps PFBMFT1, anticorps TCS1, anticorps TP2, anticorps TRT, anticorps hEST2, anticorps hTRT, anticorps chTERT, anticorps Tert, anticorps ATTERT, anticorps F5E19.190, anticorps F5E19_190, anticorps telomerase reverse transcriptase, anticorps tert, anticorps TR, anticorps est2, anticorps tcs1, anticorps telomerase, anticorps tert-A, anticorps tp2, anticorps trt, anticorps xTERT, anticorps telomerase reverse transcriptase, anticorps Telomerase Reverse Transcriptase, anticorps Tertp, anticorps Telomerase catalytic subunit, anticorps telomerase reverse transcriptase L homeolog, anticorps TERT, anticorps trt-1, anticorps Tert, anticorps tert, anticorps CMU_003490, anticorps VDBG_04487, anticorps GL50803_16225, anticorps tert.L
- Sujet
-
Description: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis.
Gene: TERT
- Poids moléculaire
- 127 kDa
- ID gène
- 7015
- UniProt
- O14746
- Pathways
- Telomere Maintenance
-