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THO Complex 5 anticorps (Internal Region)

THOC5 Reactivité: Humain ELISA, WB, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6265558
  • Antigène Voir toutes THO Complex 5 (THOC5) Anticorps
    THO Complex 5 (THOC5)
    Épitope
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 26
    • 8
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 25
    • 1
    Lapin
    Clonalité
    • 26
    Polyclonal
    Conjugué
    • 16
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp THO Complex 5 est non-conjugé
    Application
    • 13
    • 9
    • 8
    • 5
    • 3
    • 3
    • 1
    ELISA, Western Blotting (WB), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    THOC5 Antibody detects endogenous levels of total THOC5.
    Homologie
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human THOC5, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product THOC5 Anticorps primaire
  • Indications d'application
    WB 1:1000-3000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    THO Complex 5 (THOC5)
    Autre désignation
    THOC5 (THOC5 Produits)
    Synonymes
    anticorps C22orf19, anticorps Fmip, anticorps PK1.3, anticorps fSAP79, anticorps 1700060C24Rik, anticorps A430085L24Rik, anticorps Sgk2, anticorps fc54b09, anticorps wu:fc54b09, anticorps zgc:56190, anticorps zgc:76912, anticorps THOC5, anticorps fmip, anticorps thoc5, anticorps thoc5-a, anticorps thoc5-b, anticorps THO complex 5, anticorps THO complex 5 S homeolog, anticorps THO complex 5 L homeolog, anticorps THOC5, anticorps Thoc5, anticorps thoc5, anticorps thoc5.S, anticorps thoc5.L
    Sujet

    Description: Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. THOC5 in conjunction with ALYREF/THOC4 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA, both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in transcription elongation and genome stability. Involved in alternative polyadenylation site choice by recruiting CPSF6 to 5' region of target genes, probably mediates association of the TREX and CFIm complexes.

    Gene: THOC5

    Poids moléculaire
    79 kDa
    ID gène
    8563
    UniProt
    Q13769
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