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TJP3 anticorps (C-Term)

TJP3 Reactivité: Humain, Rat, Souris WB, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6265590
  • Antigène Voir toutes TJP3 Anticorps
    TJP3 (Tight Junction Protein 3 (Zona Occludens 3) (TJP3))
    Épitope
    • 10
    • 9
    • 7
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 30
    • 11
    • 11
    • 1
    Humain, Rat, Souris
    Hôte
    • 34
    • 2
    Lapin
    Clonalité
    • 35
    • 1
    Polyclonal
    Conjugué
    • 19
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp TJP3 est non-conjugé
    Application
    • 28
    • 16
    • 5
    • 5
    • 4
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Specificité
    TJP3 Antibody detects endogenous levels of total TJP3.
    Homologie
    Pig,Dog,Chicken
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human TJP3, corresponding to a region within C-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product TJP3 Anticorps primaire
  • Indications d'application
    WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    TJP3 (Tight Junction Protein 3 (Zona Occludens 3) (TJP3))
    Autre désignation
    TJP3 (TJP3 Produits)
    Synonymes
    anticorps cb766, anticorps wu:fj93c08, anticorps zo-3, anticorps zo3, anticorps ZO-3, anticorps ZO3, anticorps tight junction protein 3, anticorps tight junction protein 3 S homeolog, anticorps tjp3, anticorps tjp3.S, anticorps TJP3, anticorps Tjp3
    Sujet

    Description: TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates to the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity).

    Gene: TJP3

    Poids moléculaire
    101 kDa
    ID gène
    27134
    UniProt
    O95049
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