TJP3 anticorps (C-Term)
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- Antigène Voir toutes TJP3 Anticorps
- TJP3 (Tight Junction Protein 3 (Zona Occludens 3) (TJP3))
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Épitope
- C-Term
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Reactivité
- Humain, Rat, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp TJP3 est non-conjugé
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Application
- Western Blotting (WB), ELISA
- Specificité
- TJP3 Antibody detects endogenous levels of total TJP3.
- Homologie
- Pig,Dog,Chicken
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human TJP3, corresponding to a region within C-terminal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product TJP3 Anticorps primaire
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- Indications d'application
- WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- TJP3 (Tight Junction Protein 3 (Zona Occludens 3) (TJP3))
- Autre désignation
- TJP3 (TJP3 Produits)
- Synonymes
- anticorps cb766, anticorps wu:fj93c08, anticorps zo-3, anticorps zo3, anticorps ZO-3, anticorps ZO3, anticorps tight junction protein 3, anticorps tight junction protein 3 S homeolog, anticorps tjp3, anticorps tjp3.S, anticorps TJP3, anticorps Tjp3
- Sujet
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Description: TJP1, TJP2, and TJP3 are closely related scaffolding proteins that link tight junction (TJ) transmembrane proteins such as claudins, junctional adhesion molecules, and occludin to the actin cytoskeleton (PubMed:16129888). The tight junction acts to limit movement of substances through the paracellular space and as a boundary between the compositionally distinct apical and basolateral plasma membrane domains of epithelial and endothelial cells. Binds and recruits PATJ to tight junctions where it connects and stabilizes apical and lateral components of tight junctions (PubMed:16129888). Promotes cell-cycle progression through the sequestration of cyclin D1 (CCND1) at tight junctions during mitosis which prevents CCND1 degradation during M-phase and enables S-phase transition (PubMed:21411630). With TJP1 and TJP2, participates to the junctional retention and stability of the transcription factor DBPA, but is not involved in its shuttling to the nucleus (By similarity). Contrary to TJP2, TJP3 is dispensable for individual viability, embryonic development, epithelial differentiation, and the establishment of TJs, at least in the laboratory environment (By similarity).
Gene: TJP3
- Poids moléculaire
- 101 kDa
- ID gène
- 27134
- UniProt
- O95049
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