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TOP1MT anticorps (Internal Region)

TOP1MT Reactivité: Humain, Souris, Rat WB, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6265672
  • Antigène Voir toutes TOP1MT Anticorps
    TOP1MT (Topoisomerase (DNA) I, Mitochondrial (TOP1MT))
    Épitope
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 28
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 18
    • 12
    Lapin
    Clonalité
    • 16
    • 14
    Polyclonal
    Conjugué
    • 14
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp TOP1MT est non-conjugé
    Application
    • 11
    • 10
    • 10
    • 9
    • 7
    • 3
    • 3
    • 2
    Western Blotting (WB), ELISA
    Specificité
    TOP1MT Antibody detects endogenous levels of total TOP1MT.
    Homologie
    Pig,Zebrafish,Horse,Sheep,Chicken
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human TOP1MT, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product TOP1MT Anticorps primaire
  • Indications d'application
    WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    TOP1MT (Topoisomerase (DNA) I, Mitochondrial (TOP1MT))
    Autre désignation
    TOP1MT (TOP1MT Produits)
    Synonymes
    anticorps 2900052H09Rik, anticorps TOP1, anticorps topoisomerase (DNA) I, mitochondrial, anticorps DNA topoisomerase 1, mitochondrial, anticorps DNA topoisomerase I mitochondrial, anticorps TOP1MT, anticorps Top1mt
    Sujet

    Description: Releases the supercoiling and torsional tension of DNA introduced during duplication of mitochondrial DNA by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity).

    Gene: TOP1MT

    Poids moléculaire
    70 kDa
    ID gène
    116447
    UniProt
    Q969P6
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