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TP53INP1 anticorps (Internal Region)

TP53INP1 Reactivité: Humain, Souris WB, ELISA, IHC, IF, ICC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6265680
  • Antigène Voir toutes TP53INP1 Anticorps
    TP53INP1 (Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1))
    Épitope
    • 12
    • 10
    • 8
    • 8
    • 7
    • 6
    • 5
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region
    Reactivité
    • 54
    • 27
    • 12
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris
    Hôte
    • 61
    Lapin
    Clonalité
    • 52
    • 8
    Polyclonal
    Conjugué
    • 24
    • 6
    • 6
    • 5
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp TP53INP1 est non-conjugé
    Application
    • 42
    • 33
    • 30
    • 12
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Specificité
    TP53INP1 Antibody detects endogenous levels of total TP53INP1.
    Homologie
    Pig,Bovine,Horse,Sheep,Rabbit,Dog
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human TP53INP1, corresponding to a region within the internal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product TP53INP1 Anticorps primaire
  • Indications d'application
    WB 1:1000-3000, IF/ICC 1:100-1:500, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    TP53INP1 (Tumor Protein P53 Inducible Nuclear Protein 1 (TP53INP1))
    Autre désignation
    TP53INP1 (TP53INP1 Produits)
    Synonymes
    anticorps cb1036, anticorps wu:fb70a09, anticorps wu:fi13h08, anticorps zgc:158431, anticorps TP53INP1, anticorps 2700057G22Rik, anticorps SIP, anticorps SIP18, anticorps SIP27, anticorps Stinp, anticorps Teap, anticorps TP53DINP1, anticorps TP53INP1A, anticorps TP53INP1B, anticorps p53DINP1, anticorps Trp53inp1, anticorps tumor protein p53 inducible nuclear protein 1, anticorps tumor protein p53 inducible nuclear protein 1 S homeolog, anticorps transformation related protein 53 inducible nuclear protein 1, anticorps TP53INP1, anticorps tp53inp1.S, anticorps tp53inp1, anticorps Trp53inp1, anticorps Tp53inp1
    Sujet

    Description: Antiproliferative and proapoptotic protein involved in cell stress response which acts as a dual regulator of transcription and autophagy. Acts as a positive regulator of autophagy. In response to cellular stress or activation of autophagy, relocates to autophagosomes where it interacts with autophagosome-associated proteins GABARAP, GABARAPL1/L2, MAP1LC3A/B/C and regulates autophagy. Acts as an antioxidant and plays a major role in p53/TP53-driven oxidative stress response. Possesses both a p53/TP53-independent intracellular reactive oxygen species (ROS) regulatory function and a p53/TP53-dependent transcription regulatory function. Positively regulates p53/TP53 and p73/TP73 and stimulates their capacity to induce apoptosis and regulate cell cycle. In response to double-strand DNA breaks, promotes p53/TP53 phosphorylation on 'Ser-46' and subsequent apoptosis. Acts as a tumor suppressor by inducing cell death by an autophagy and caspase-dependent mechanism. Can reduce cell migration by regulating the expression of SPARC.

    Gene: TP53INP1

    Poids moléculaire
    27 kDa
    ID gène
    94241
    UniProt
    Q96A56
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