UBR2 anticorps (C-Term)
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- Antigène Voir toutes UBR2 Anticorps
- UBR2 (Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2))
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Épitope
- C-Term
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp UBR2 est non-conjugé
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
- Specificité
- UBR2 Antibody detects endogenous levels of total UBR2.
- Homologie
- Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
- Purification
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- Immunogène
- A synthesized peptide derived from human UBR2, corresponding to a region within C-terminal amino acids.
- Isotype
- IgG
- Top Product
- Discover our top product UBR2 Anticorps primaire
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- Indications d'application
- WB 1:1000-3000, IHC 1:200, ELISA(peptide) 1:20000-1:40000
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20 °C. Stable for 12 months from date of receipt.
- Date de péremption
- 12 months
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- Antigène
- UBR2 (Ubiquitin Protein Ligase E3 Component N-Recognin 2 (UBR2))
- Autre désignation
- UBR2 (UBR2 Produits)
- Synonymes
- anticorps ba49a4.1, anticorps si:ch211-239i4.2, anticorps C6orf133, anticorps RP3-392M17.3, anticorps bA49A4.1, anticorps dJ242G1.1, anticorps dJ392M17.3, anticorps 9930021A08Rik, anticorps AI462103, anticorps AW540746, anticorps E130209G04Rik, anticorps mKIAA0349, anticorps ubiquitin protein ligase E3 component n-recognin 2, anticorps ubiquitin protein ligase E3 component n-recognin 2 S homeolog, anticorps UBR2, anticorps ubr2, anticorps ubr2.S, anticorps Ubr2
- Sujet
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Description: E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. Required for spermatogenesis, promotes, with Tex19.1, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity). Polyubiquitinates LINE-1 retrotransposon encoded, LIRE1, which induces degradation, inhibiting LINE-1 retranstoposon mobilization (By similarity).
Gene: UBR2
- Poids moléculaire
- 201kDa
- ID gène
- 23304
- UniProt
- Q8IWV8
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