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USP10 anticorps (N-Term)

USP10 Reactivité: Humain, Souris, Rat WB, ELISA, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6265909
  • Antigène Voir toutes USP10 Anticorps
    USP10 (Ubiquitin Specific Peptidase 10 (USP10))
    Épitope
    • 7
    • 7
    • 6
    • 6
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 70
    • 25
    • 24
    • 5
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 62
    • 8
    Lapin
    Clonalité
    • 54
    • 16
    Polyclonal
    Conjugué
    • 36
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp USP10 est non-conjugé
    Application
    • 58
    • 20
    • 15
    • 14
    • 10
    • 9
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Specificité
    USP10 Antibody detects endogenous levels of total USP10.
    Homologie
    Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human USP10, corresponding to a region within N-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product USP10 Anticorps primaire
  • Indications d'application
    WB 1:1000-3000, IHC 1:50-1:200, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    USP10 (Ubiquitin Specific Peptidase 10 (USP10))
    Autre désignation
    USP10 (USP10 Produits)
    Synonymes
    anticorps T4F9.30, anticorps T4F9_30, anticorps ubiquitin-specific protease 9, anticorps ubpo, anticorps USP10, anticorps id:ibd1190, anticorps wu:fc19h08, anticorps wu:fc76g05, anticorps wu:fi11g01, anticorps UBPO, anticorps 2610014N07Rik, anticorps Uchrp, anticorps mKIAA0190, anticorps usp10-A, anticorps ubiquitin specific peptidase 10, anticorps universal stress protein UspA, anticorps ubiquitin-specific protease 9, anticorps ubiquitin carboxyl-terminal hydrolase 10, anticorps ubiquitin specific peptidase 10 S homeolog, anticorps USP10, anticorps RR_RS14970, anticorps UBP9, anticorps PTRG_07201, anticorps MGYG_06403, anticorps usp10, anticorps Usp10, anticorps usp10.S
    Sujet

    Description: Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, BECN1, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Component of a regulatory loop that controls autophagy and p53/TP53 levels: mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. In turn, PIK3C3/VPS34-containing complexes regulate USP10 stability, suggesting the existence of a regulatory system by which PIK3C3/VPS34-containing complexes regulate p53/TP53 protein levels via USP10 and USP13. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling. Involved in a TANK-dependent negative feedback response to attenuate NF-kappaB activation via deubiquitinating IKBKG or TRAF6 in response to interleukin-1-beta (IL1B) stimulation or upon DNA damage (PubMed:25861989). Deubiquitinates TBX21 leading to its stabilization (PubMed:24845384).

    Gene: USP10

    Poids moléculaire
    87 kDa
    ID gène
    9100
    UniProt
    Q14694
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