VPS11 anticorps (Internal Region)

N° du produit ABIN6265995

Détail du produit anti-VPS11 anticorps

Antigène: VPS11 (Vacuolar Protein Sorting 11 Homolog (VPS11))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp VPS11 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: VPS11 Antibody detects endogenous levels of total VPS11.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human VPS11, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur VPS11

Antigène: VPS11 (Vacuolar Protein Sorting 11 Homolog (VPS11))

Autre désignation: VPS11 (VPS11 Produits)

Synonymes: anticorps zgc:112329, anticorps ATVPS11, anticorps F5G3.7, anticorps F5G3_7, anticorps vacuolar protein sorting 11, anticorps DDBDRAFT_0204454, anticorps DDBDRAFT_0234135, anticorps DDB_0204454, anticorps DDB_0234135, anticorps end1, anticorps pep5, anticorps hvps11, anticorps rnf108, anticorps 1200011A11Rik, anticorps END1, anticorps PEP5, anticorps RNF108, anticorps hVPS11, anticorps VPS11, CORVET/HOPS core subunit, anticorps vacuolar protein sorting 11, anticorps vacuolar protein sorting protein 11, anticorps VPS11, CORVET/HOPS core subunit S homeolog, anticorps Vacuolar peripheral membrane protein similar to S. cerevisiae PEP5 (YMR231W); C terminus is almost identical to nonallelic CaP19.1278, anticorps 7-fold repeat in clathrin and VPS proteins repeat-containing protein, anticorps vacuolar protein sorting-associated protein 11 homolog, anticorps VPS11 CORVET/HOPS core subunit, anticorps VPS11, anticorps vps11, anticorps MCYG_02909, anticorps vps11.S, anticorps LOC100632536, anticorps Vps11

Sujet:

Description: Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25266290, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in cargo transport from early to late endosomes and required for the transition from early to late endosomes (PubMed:21148287). Involved in the retrograde Shiga toxin transport (PubMed:23593995).

Gene: VPS11

Poids moléculaire: 108-112 kDa

ID gène: 55823

UniProt: Q9H270

Pathways: SARS-CoV-2 Protein Interactome