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XPO4 anticorps (N-Term)

XPO4 Reactivité: Humain, Souris, Rat WB, IHC, ELISA, ICC, IF Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6266065
  • Antigène Voir toutes XPO4 Anticorps
    XPO4 (Exportin 4 (XPO4))
    Épitope
    • 1
    • 1
    • 1
    • 1
    N-Term
    Reactivité
    • 11
    • 10
    • 10
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 10
    • 1
    Lapin
    Clonalité
    • 10
    • 1
    Polyclonal
    Conjugué
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp XPO4 est non-conjugé
    Application
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF)
    Specificité
    XPO4 Antibody detects endogenous levels of total XPO4.
    Homologie
    Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human XPO4, corresponding to a region within N-terminal amino acids.
    Isotype
    IgG
  • Indications d'application
    WB 1:1000-3000, IHC 1:200, IF/ICC 1:200-1:500, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    XPO4 (Exportin 4 (XPO4))
    Autre désignation
    XPO4 (XPO4 Produits)
    Synonymes
    anticorps XPO4, anticorps MGC157258, anticorps DDBDRAFT_0215248, anticorps DDBDRAFT_0237580, anticorps DDB_0215248, anticorps DDB_0237580, anticorps exp4, anticorps B430309A01Rik, anticorps mKIAA1721, anticorps fc26b07, anticorps wu:fc26b07, anticorps wu:fi43b10, anticorps zgc:55678, anticorps exportin 4, anticorps exportin 4 L homeolog, anticorps XPO4, anticorps xpo4, anticorps Xpo4, anticorps xpo4.L
    Sujet

    Description: Mediates the nuclear export of proteins (cargos) with broad substrate specificity. In the nucleus binds cooperatively to its cargo and to the GTPase Ran in its active GTP-bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. XPO4 then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

    Gene: XPO4

    Poids moléculaire
    127 kDa
    ID gène
    64328
    UniProt
    Q9C0E2
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