ZNF598 anticorps (N-Term)

N° du produit ABIN6266100

Détail du produit anti-ZNF598 anticorps

Antigène: ZNF598 (Zinc Finger Protein 598 (ZNF598))

Épitope: N-Term

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZNF598 est non-conjugé

Application: Western Blotting (WB), ELISA

Specificité: ZFP598 Antibody detects endogenous levels of total ZFP598.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human ZFP598, corresponding to a region within N-terminal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur ZNF598

Antigène: ZNF598 (Zinc Finger Protein 598 (ZNF598))

Autre désignation: ZNF598 (ZNF598 Produits)

Synonymes: anticorps ZNF598, anticorps BC023040, anticorps Ntrap, anticorps Znf598, anticorps Zfp598, anticorps wu:fc88f12, anticorps zinc finger protein 598, anticorps ZNF598, anticorps znf598, anticorps Zfp598

Sujet:

Description: E3 ubiquitin-protein ligase that plays a key role in the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation (PubMed:28065601, PubMed:28132843). Required for ribosomes to terminally stall during translation of poly(A) sequences by mediating monoubiquitination of 40S ribosomal protein RPS10/eS10, RPS20/uS10 and RPS3/uS3 (PubMed:28065601, PubMed:28132843). Stalling precludes synthesis of a long poly-lysine tail and initiates the RQC pathway to degrade the potentially detrimental aberrant nascent polypeptide (PubMed:28065601, PubMed:28132843). Also acts as a component of the 4EHP-GYF2 complex, a multiprotein complex that acts as a repressor of translation initiation (PubMed:22751931).

Gene: ZNF598

Poids moléculaire: 98 kDa

ID gène: 90850

UniProt: Q86UK7