ZIC1/2/3 anticorps

N° du produit ABIN6266105

Détail du produit anti-ZIC1/2/3 anticorps

Antigène: ZIC1/2/3 (Zic1/2/3/4/5) (Zic Family Member 1/2/3/4/5 (Zic1/2/3/4/5))

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZIC1/2/3 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Specificité: ZIC1/2/3 antibody detects endogenous levels of total ZIC1/2/3

Réactivité croisée: Humain, Souris

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human ZIC1/2/3

Isotype: IgG

Information d'application

Indications d'application: WB: 1:500~1:3000 IHC: 1:50~1:200, IF/ICC 1:100-1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline ,  pH 7.4, 150  mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C.Stable for 12 months from date of receipt

Date de péremption: 12 months

Détails sur ZIC1/2/3

Antigène: ZIC1/2/3 (Zic1/2/3/4/5) (Zic Family Member 1/2/3/4/5 (Zic1/2/3/4/5))

Autre désignation: ZIC1/2/3 (Zic1/2/3/4/5 Produits)

Sujet:

Description: Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity).

Gene: ZIC1

Poids moléculaire: 51kDa

ID gène: 7545

UniProt: Q15915, O95409, O60481