ZNRF1 anticorps (Internal Region)

N° du produit ABIN6266142

Détail du produit anti-ZNRF1 anticorps

Antigène: ZNRF1 (Zinc and Ring Finger Protein 1 (ZNRF1))

Épitope: Internal Region

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ZNRF1 est non-conjugé

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Immunofluorescence (IF)

Specificité: ZNRF1 Antibody detects endogenous levels of total ZNRF1.

Homologie: Pig,Zebrafish,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Purification: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogène: A synthesized peptide derived from human ZNRF1, corresponding to a region within the internal amino acids.

Isotype: IgG

Information d'application

Indications d'application: WB 1:1000-3000, IHC 1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20 °C. Stable for 12 months from date of receipt.

Date de péremption: 12 months

Détails sur ZNRF1

Antigène: ZNRF1 (Zinc and Ring Finger Protein 1 (ZNRF1))

Autre désignation: ZNRF1 (ZNRF1 Produits)

Synonymes: anticorps NIN283, anticorps B830022L21Rik, anticorps Rnf42, anticorps Zrfp1, anticorps nin283, anticorps zgc:77896, anticorps zrfp1, anticorps zinc and ring finger 1, anticorps zinc and ring finger 1, E3 ubiquitin protein ligase S homeolog, anticorps ZNRF1, anticorps Znrf1, anticorps znrf1, anticorps znrf1.S

Sujet:

Description: E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable).

Gene: ZNRF1

Poids moléculaire: 24 kDa

ID gène: 84937

UniProt: Q8ND25