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RHOA anticorps (C-Term)

RHOA Reactivité: Humain, Souris, Rat WB, ELISA Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN6266371
  • Antigène Voir toutes RHOA Anticorps
    RHOA (Ras Homolog Gene Family, Member A (RHOA))
    Épitope
    • 16
    • 7
    • 6
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 71
    • 40
    • 40
    • 1
    • 1
    Humain, Souris, Rat
    Hôte
    • 58
    • 12
    • 1
    Lapin
    Clonalité
    • 50
    • 21
    Polyclonal
    Conjugué
    • 34
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp RHOA est non-conjugé
    Application
    • 48
    • 26
    • 22
    • 16
    • 14
    • 13
    • 12
    • 7
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA
    Specificité
    RhoA Antibody detects endogenous levels of total RhoA.
    Homologie
    Pig,Bovine,Sheep,Dog
    Purification
    The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
    Immunogène
    A synthesized peptide derived from human RhoA, corresponding to a region within C-terminal amino acids.
    Isotype
    IgG
    Top Product
    Discover our top product RHOA Anticorps primaire
  • Indications d'application
    WB 1:500-1:2000, ELISA(peptide) 1:20000-1:40000
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    -20 °C
    Stockage commentaire
    Store at -20 °C. Stable for 12 months from date of receipt.
    Date de péremption
    12 months
  • Antigène
    RHOA (Ras Homolog Gene Family, Member A (RHOA))
    Autre désignation
    RHOA (RHOA Produits)
    Synonymes
    anticorps ARH12, anticorps ARHA, anticorps RHO12, anticorps RHOH12, anticorps Arha, anticorps Arha1, anticorps Arha2, anticorps arha, anticorps arha2, anticorps xrhoa, anticorps arh12, anticorps rho12, anticorps rhoh12, anticorps rhoa, anticorps RHO1, anticorps Rhoa, anticorps wu:fa66g04, anticorps wu:fb26g07, anticorps zgc:66058, anticorps zgc:85805, anticorps ARHC, anticorps rhoae, anticorps zgc:64015, anticorps ras homolog family member A, anticorps ras homolog family member A S homeolog, anticorps ras homolog family member A L homeolog, anticorps ras homolog gene family, member Aa, anticorps ras homolog family member Ca, anticorps RHOA, anticorps Rhoa, anticorps rhoa.S, anticorps rhoa, anticorps rhoa.L, anticorps rhoaa, anticorps rhoca
    Sujet

    Description: Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation, promotes KCNA2 endocytosis (PubMed:9635436, PubMed:19403695).

    Gene: RHOA

    Poids moléculaire
    22kDa
    ID gène
    387
    UniProt
    P61586
    Pathways
    Dynamique des Microtubules, Signalisation WNT, Neurotrophin Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Regulation of Actin Filament Polymerization, Cell-Cell Junction Organization, Positive Regulation of Endopeptidase Activity, Signaling Events mediated by VEGFR1 and VEGFR2, Thromboxane A2 Receptor Signaling, SARS-CoV-2 Protein Interactome
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