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HMGCR anticorps
HMGCR
Reactivité: Humain, Souris
WB, IHC
Hôte: Lapin
Polyclonal
unconjugated
N° du produit ABIN6293218
Détail du produit anti-HMGCR anticorps
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Antigène
Voir toutes HMGCR Anticorps
HMGCR
(3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))
Reactivité
Toutes les réactivités sur HMGCR Anticorps
Humain, Souris
Hôte
Toutes les hôtes sur HMGCR Anticorps
Lapin
Clonalité
Toutes les clonalités sur HMGCR Anticorps
Polyclonal
Conjugué
Tous les conjugués à travers HMGCR Anticorps
Cet anticorp HMGCR est non-conjugé
Application
Tous les applications à travers HMGCR Anticorps.
Western Blotting (WB), Immunohistochemistry (IHC)
Purification
Affinity purification
Immunogène
Recombinant protein of human HMGCR
Isotype
IgG
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Discover our top product HMGCR Anticorps primaire
Alternatives
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Information d'application
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Indications d'application
WB 1:500 - 1:2000 IHC 1:50 - 1:200
Restrictions
For Research Use only
Stockage
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Buffer
PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
-20 °C
Stockage commentaire
Store at -20C. Avoid freeze / thaw cycles.
Détails sur HMGCR
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Antigène
HMGCR
(3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR))
Autre désignation
HMGCR (HMGCR Produits )
Synonymes
anticorps HMGR, anticorps LDLCQ3, anticorps hmg-coa-r, anticorps HMG-CoAR, anticorps Red, anticorps 3H3M, anticorps BcDNA:LD15354, anticorps CG10367, anticorps Clb, anticorps DmHMG-CoAr, anticorps Dmel\\CG10367, anticorps HMGCR, anticorps HMGCR_Dm, anticorps HMGCoAR, anticorps HMGCoARr, anticorps HMGCoAr, anticorps HmG-CoAR, anticorps Hmg, anticorps bro1, anticorps bs32f05.y1, anticorps clb, anticorps hmgc, anticorps hmgcr, anticorps hmgrc, anticorps l(3)01152, anticorps l(3)04684, anticorps hmgcr2, anticorps im:6912716, anticorps zgc:110746, anticorps 3-hydroxy-3-methylglutaryl-CoA reductase, anticorps 3-hydroxy-3-methylglutaryl-CoA reductase L homeolog, anticorps 3-hydroxy-3-methylglutaryl-Coenzyme A reductase, anticorps HMG Coenzyme A reductase, anticorps 3-hydroxy-3-methylglutaryl-CoA reductase b, anticorps HMGCR, anticorps hmgcr.L, anticorps Hmgcr, anticorps hmgcrb
Sujet
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Poids moléculaire
97.476 kDa
ID gène
3156
UniProt
P04035
Pathways
AMPK Signaling , Negative Regulation of Hormone Secretion , Regulation of Lipid Metabolism by PPARalpha
Vus récemment
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