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ACTN2 anticorps (C-Term)

ACTN2 Reactivité: Humain, Souris, Rat, Chien WB, IHC Hôte: Lapin Polyclonal unconjugated
N° du produit ABIN629641
  • Antigène Voir toutes ACTN2 Anticorps
    ACTN2 (Actinin, alpha 2 (ACTN2))
    Épitope
    • 15
    • 13
    • 9
    • 7
    • 7
    • 6
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    C-Term
    Reactivité
    • 62
    • 50
    • 34
    • 8
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    Humain, Souris, Rat, Chien
    Hôte
    • 73
    • 11
    Lapin
    Clonalité
    • 64
    • 20
    Polyclonal
    Conjugué
    • 40
    • 7
    • 6
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp ACTN2 est non-conjugé
    Application
    • 65
    • 21
    • 20
    • 14
    • 13
    • 12
    • 10
    • 10
    • 7
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC)
    Specificité
    Alpha Actinin 2 antibody was raised against the C terminal of ACTN2
    Purification
    Purified
    Immunogène
    alpha Actinin 2 antibody was raised using the C terminal of ACTN2 corresponding to a region with amino acids VIASFRILASDKPYILAEELRRELPPDQAQYCIKRMPAYSGPGSVPGALD
    Top Product
    Discover our top product ACTN2 Anticorps primaire
  • Indications d'application
    WB: 1.25 µg/mL, IHC: 4-8 µg/mL
    Optimal conditions should be determined by the investigator.
    Commentaires

    Alpha Actinin 2 Blocking Peptide, catalog no. 33R-9587, is also available for use as a blocking control in assays to test for specificity of this Alpha Actinin 2 antibody

    Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Lyophilized powder. Add distilled water for a 1 mg/mL concentration of ACTN2 antibody in PBS
    Concentration
    Lot specific
    Buffer
    PBS
    Conseil sur la manipulation
    Avoid repeated freeze/thaw cycles.
    Dilute only prior to immediate use.
    Stock
    4 °C/-20 °C
    Stockage commentaire
    Store at 2-8 °C for short periods. For longer periods of storage, store at -20 °C.
  • Chopra, Kutys, Zhang, Polacheck, Sheng, Luu, Eyckmans, Hinson, Seidman, Seidman, Chen: "Force Generation via β-Cardiac Myosin, Titin, and α-Actinin Drives Cardiac Sarcomere Assembly from Cell-Matrix Adhesions." dans: Developmental cell, Vol. 44, Issue 1, pp. 87-96.e5, (2018) (PubMed).

  • Antigène
    ACTN2 (Actinin, alpha 2 (ACTN2))
    Autre désignation
    alpha Actinin 2 (ACTN2 Produits)
    Synonymes
    anticorps MGC89234, anticorps ACTN2, anticorps 1110008F24Rik, anticorps CMD1AA, anticorps wu:fd44c03, anticorps zgc:123223, anticorps actinin alpha 2, anticorps actinin, alpha 2b, anticorps actinin alpha 2 S homeolog, anticorps actn2, anticorps ACTN2, anticorps Actn2, anticorps actn2b, anticorps actn2.S
    Sujet
    The alpha-actinins are a multigene family of four actin-binding proteins related to dystrophin. The two skeletal muscle isoforms of alpha-actinin (ACTN2 and ACTN3) are major structural components of the Z-line involved in anchoring the actin-containing thin filaments. In humans, ACTN2 is expressed in all muscle fibres, while ACTN3 expression is restricted to a subset of type 2 fibres. Murine Actn2 and Actn3 are differentially expressed, spatially and temporally, during embryonic development and, in contrast to humans, alpha-actinin-2 expression does not completely overlap alpha-actinin-3 in postnatal skeletal muscle, suggesting independent function.
    Poids moléculaire
    98 kDa (MW of target protein)
    Pathways
    Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Negative Regulation of Transporter Activity
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