TYMS anticorps
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- Antigène Voir toutes TYMS Anticorps
- TYMS (Thymidylate Synthetase (TYMS))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp TYMS est non-conjugé
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Application
- Immunohistochemistry (IHC)
- Fonction
- Mouse anti-Human Thymidylate Synthase Antibody [IHC only]
- Specificité
- Cytoplasmic
- Purification
- Recombinant human Thymidylate synthase was used as the immunogen for this antibody.
- Immunogène
- Recombinant human Thymidylate synthase was used as the immunogen for this antibody.
- Top Product
- Discover our top product TYMS Anticorps primaire
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- Indications d'application
- Prediluted format : incubate for 30 min at RT (2)
- Restrictions
- For Research Use only
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- Buffer
- Prediluted in 1X PBS ( pH 7.4) with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- Antigène
- TYMS (Thymidylate Synthetase (TYMS))
- Autre désignation
- Thymidylate synthase (TYMS Produits)
- Synonymes
- anticorps FN1, anticorps ECK2823, anticorps JW2795, anticorps ts, anticorps Ts, anticorps HST422, anticorps TMS, anticorps TS, anticorps thymidylate synthetase, anticorps contains intron in T4 phage, anticorps ThyE, anticorps thymidylate synthase, anticorps thymidylate synthetase L homeolog, anticorps TYMS, anticorps thyA, anticorps td, anticorps thyE, anticorps DDA3937_RS04960, anticorps tyms.L, anticorps XBJ1_RS15770, anticorps EAMY_RS20680, anticorps Tyms
- Classe de substances
- Viral Protein
- Sujet
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Target Description: This antibody is specific for a protein of 36 kDa, identified as Thymidylate Synthase (TS). Thymidylate synthase converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. Thymidylate synthase is also a critical target for the fluoropyrimidines, an important group of anti-neoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates thymidylate synthase by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of thymidylate synthase protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
Gene Symbol: TYMS///TS///OK///SW-cl.29
- ID gène
- 7298
- UniProt
- P04818
- Pathways
- Mitotic G1-G1/S Phases
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