Melanoma gp100 anticorps
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- Antigène Voir toutes Melanoma gp100 (PMEL) Anticorps
- Melanoma gp100 (PMEL) (Premelanosome Protein (PMEL))
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Reactivité
- Humain
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Hôte
- Souris
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Clonalité
- Monoclonal
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Conjugué
- Cet anticorp Melanoma gp100 est non-conjugé
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Application
- Immunohistochemistry (IHC)
- Fonction
- Mouse anti-Human gp100 Antibody [IHC only]
- Specificité
- Cytoplasmic
- Purification
- The extract of pigmented melanoma metastases from lymph nodes was used as the immunogen for this gp100 antibody.
- Immunogène
- The extract of pigmented melanoma metastases from lymph nodes was used as the immunogen for this gp100 antibody.
- Top Product
- Discover our top product PMEL Anticorps primaire
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- Indications d'application
- Prediluted format : incubate for 30 min at RT (2)
- Restrictions
- For Research Use only
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- Buffer
- Prediluted in 1X PBS ( pH 7.4) with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide, For IHC use only
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- 2-8°C. The azide-free format should be aliquoted and stored at -20°C or colder.
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- Antigène
- Melanoma gp100 (PMEL) (Premelanosome Protein (PMEL))
- Autre désignation
- Melanocyte protein PMEL , M-beta] (PMEL Produits)
- Synonymes
- anticorps D12S53E, anticorps ME20, anticorps ME20-M, anticorps ME20M, anticorps P1, anticorps P100, anticorps PMEL17, anticorps SI, anticorps SIL, anticorps SILV, anticorps gp100, anticorps D10H12S53E, anticorps D12S53Eh, anticorps Pmel17, anticorps Si, anticorps Silv, anticorps gp87, anticorps RPE1, anticorps MMP115, anticorps silverb, anticorps silver, anticorps cb397, anticorps fdv, anticorps pmel17, anticorps sb:cb397, anticorps silva, anticorps wu:fc11g11, anticorps wu:fj24g11, anticorps zgc:136622, anticorps premelanosome protein, anticorps premelanosome protein b, anticorps premelanosome protein a, anticorps PMEL, anticorps Pmel, anticorps pmelb, anticorps pmela
- Sujet
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Target Description: Melanocytes produce organelles called melanosomes which produce melanin, the pigment that gives color to skin, hair, eyes, scales and feathers. gp100 was identified in an attempt to clone the gene Tyrosinase, an enzyme required for melanin synthesis. Further testing determined that gp100 is a melanoma-specific protein and is responsible for melanosome maturation, facilitating the transition from amorphous rounded vesicles to fibrillary ellipsoid organelles.
Metastatic amelanotic melanoma can often be confused with a variety of poorly differentiated carcinomas, large cell lymphomas, and sarcomas using H & E stains alone. It is also difficult to differentiate melanoma from spindle cell carcinomas and various types of mesenchymal neoplasms. Clone HMB45 gp100 antibody stains fetal and neonatal melanocytes, junctional and blue nevus cells, and malignant melanoma. It also stains angiomyolipomas, tumors most commonly associated with the kidney. Intradermal nevi, normal adult melanocytes, and non-melanocytic cells are negative. This gp100 antibody does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin.Gene Symbol: PMEL///D12S53E///PMEL17///SILV
- ID gène
- 6490
- UniProt
- P40967
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