LAMP2 anticorps

N° du produit ABIN638447

Détail du produit anti-LAMP2 anticorps

Antigène: LAMP2 (Lysosomal-Associated Membrane Protein 2 (LAMP2))

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp LAMP2 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Specificité: The mouse monoclonal antibody H4B4 recognizes an extracellular/luminal epitope of CD107b / LAMP-2, an extensively glycosylated 100-120 kDa widely expressed lysosome-associated protein.

Aucune reactivité croisée: Souris, Rat

Réactivité croisée (Details): Human

Purification: Purified by protein-A affinity chromatography.

Pureté: > 95 % (by SDS-PAGE)

Immunogène: Human PBMC

Clone: H4B4

Isotype: IgG1 kappa

Information d'application

Indications d'application: Flow cytometry: Intracellular and extracellular staining, recommended dilution: 1-2 μg/mL.
Immunohistochemistry: Recommended dilution: 2-8 μg/mL.

Restrictions: For Research Use only

Stockage

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4

Agent conservateur: Azide free

Conseil sur la manipulation: Do not freeze.

Stock: 4 °C

Stockage commentaire: Store at 2-8°C. Do not freeze.

Références pour anticorps anti-LAMP2 (ABIN638447)

Thedrez, Harly, Morice, Salot, Bonneville, Scotet: "IL-21-mediated potentiation of antitumor cytolytic and proinflammatory responses of human V gamma 9V delta 2 T cells for adoptive immunotherapy." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 182, Issue 6, pp. 3423-31, (2009) (PubMed).

Meade, Wilson, Holmes, de Wynter, Brett, Straszynski, Ballard, Trapani, McDermott, Cook: "Proteolytic activation of the cytotoxic phenotype during human NK cell development." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 2, pp. 803-13, (2009) (PubMed).

Guia, Cognet, de Beaucoudrey, Tessmer, Jouanguy, Berger, Filipe-Santos, Feinberg, Camcioglu, Levy, Al Jumaah, Al-Hajjar, Stephan, Fieschi, Abel, Brossay, Casanova, Vivier: "A role for interleukin-12/23 in the maturation of human natural killer and CD56+ T cells in vivo." dans: Blood, Vol. 111, Issue 10, pp. 5008-16, (2008) (PubMed).

Apte, Baz, Groves, Kelso, Kienzle: "Interferon-gamma and interleukin-4 reciprocally regulate CD8 expression in CD8+ T cells." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 45, pp. 17475-80, (2008) (PubMed).

Borgne-Sanchez, Dupont, Langonné, Baux, Lecoeur, Chauvier, Lassalle, Déas, Brière, Brabant, Roux, Péchoux, Briand, Hoebeke, Deniaud, Brenner, Rustin, Edelman, Rebouillat, Jacotot: "Targeted Vpr-derived peptides reach mitochondria to induce apoptosis of alphaVbeta3-expressing endothelial cells." dans: Cell death and differentiation, Vol. 14, Issue 3, pp. 422-35, (2007) (PubMed).

Kannanganat, Ibegbu, Chennareddi, Robinson, Amara: "Multiple-cytokine-producing antiviral CD4 T cells are functionally superior to single-cytokine-producing cells." dans: Journal of virology, Vol. 81, Issue 16, pp. 8468-76, (2007) (PubMed).

Palmer, Fernandez, Bisbing, Peachman, Rao, Barvir, Gunther, Burgess, Kohno, Padmanabhan, Sun: "Restricted replication and lysosomal trafficking of yellow fever 17D vaccine virus in human dendritic cells." dans: The Journal of general virology, Vol. 88, Issue Pt 1, pp. 148-56, (2006) (PubMed).

Denzer, van Eijk, Kleijmeer, Jakobson, de Groot, Geuze: "Follicular dendritic cells carry MHC class II-expressing microvesicles at their surface." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 165, Issue 3, pp. 1259-65, (2000) (PubMed).

Détails sur LAMP2

Antigène: LAMP2 (Lysosomal-Associated Membrane Protein 2 (LAMP2))

Autre désignation: CD107b (LAMP2 Produits)

Synonymes: anticorps CD107b, anticorps LAMP-2, anticorps LAMPB, anticorps LGP110, anticorps Lamp-2, anticorps Lamp-2a, anticorps Lamp-2b, anticorps Lamp-2c, anticorps Mac3, anticorps cd107b, anticorps lamp-2, anticorps lampb, anticorps LAMP2, anticorps lamp2, anticorps DKFZp459J126, anticorps LGP-B, anticorps sb:cb587, anticorps wu:fb14a06, anticorps zgc:103532, anticorps lysosomal associated membrane protein 2, anticorps lysosomal-associated membrane protein 2, anticorps lysosomal-associated membrane protein 2 S homeolog, anticorps lysosomal membrane glycoprotein 2, anticorps LAMP2, anticorps Lamp2, anticorps lamp2.S, anticorps lamp2

Sujet: Lysosomal associated membrane protein 2,CD107b (lysosome-associated membrane protein-2, LAMP-2), together with CD107a / LAMP-1, is a major constituent of lysosomal membrane. The LAMP proteins are involved in lysosome biogenesis and are required for fusion of lysosomes with phagosomes, especially CD107b is important regulator in successful phagosomal maturation. CD107b deficiency causes an accumulation of autophagosomes in many tissues leading to cardiomyopathy and myopathy (Danons disease). Immature CD107b is an approximately 45 kDa protein, but after extensive glycosylation the mature glycoprotein has about 100-120 kDa.,LAMP-2, LAMPB

ID gène: 3920

UniProt: P13473

Pathways: Autophagy