S100A8 anticorps (AA 30-110)

N° du produit ABIN6390101

Détail du produit anti-S100A8 anticorps

Antigène: S100A8 (S100 Calcium Binding Protein A8 (S100A8))

Épitope: AA 30-110

Reactivité: Humain, Souris, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp S100A8 est non-conjugé

Application: Western Blotting (WB), ELISA

Fonction: Unconjugated Rabbit polyclonal to S10A8

Specificité: S10A8 Polyclonal Antibody detects endogenous levels of protein.

Purification: S10A8 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogène: Synthesized peptide derived from human S10A8 protein.

Isotype: IgG

Information d'application

Indications d'application: WB 1:500-2000 ELISA 1:5000-20000

Commentaires:

Calprotectin (S100A8/9) is predominantly expressed in myeloid cells. Except for inflammatory conditions, the expression is restricted to a specific stage of myeloid differentiation since both proteins are expressed in circulating neutrophils and monocytes but are absent in normal tissue macrophages and lymphocytes. Under chronic inflammatory conditions, such as psoriasis and malignant disorders, also expressed in the epidermis. Found in high concentrations at local sites of inflammation or in the serum of patients with inflammatory diseases such as rheumatoid, cystic fibrosis, inflammatory bowel disease, Crohn's disease, giant cell arteritis, cystic fibrosis, Sjogren's syndrome, systemic lupus erythematosus, and progressive systemic sclerosis. Involved in the formation and deposition of amyloids in the aging prostate known as corpora amylacea inclusions. Strongly up-regulated in many tumors, including gastric, esophageal, colon, pancreatic, bladder, ovarian, thyroid, breast and skin cancers.

Restrictions: For Research Use only

Stockage

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid form in PBS containing 50 % glycerol,and 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: -20 °C

Stockage commentaire: Store at -20°C, and avoid repeat freeze-thaw cycles.

Détails sur S100A8

Antigène: S100A8 (S100 Calcium Binding Protein A8 (S100A8))

Autre désignation: S10A8 (S100A8 Produits)

Synonymes: anticorps 60B8AG, anticorps CAGA, anticorps CFAG, anticorps CGLA, anticorps CP-10, anticorps L1Ag, anticorps MA387, anticorps MIF, anticorps MRP8, anticorps NIF, anticorps P8, anticorps Mrp8, anticorps S100A8, anticorps 60B8Ag, anticorps AI323541, anticorps B8Ag, anticorps CFAg, anticorps Caga, anticorps p8, anticorps MRP-8, anticorps S100 calcium binding protein A8, anticorps S100 calcium binding protein A8 (calgranulin A), anticorps S100A8, anticorps S100a8

Poids moléculaire: 10 kDa

ID gène: 6279

UniProt: P05109

Pathways: Transition Metal Ion Homeostasis, Positive Regulation of Endopeptidase Activity, S100 Proteins