Tel:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@anticorps-enligne.fr

PTRH2 anticorps (AA 80-110)

PTRH2 Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal RB06095 unconjugated
N° du produit ABIN650622
  • Antigène Voir toutes PTRH2 Anticorps
    PTRH2 (Peptidyl-tRNA Hydrolase 2 (PTRH2))
    Épitope
    • 13
    • 11
    • 11
    • 6
    • 6
    • 6
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 80-110
    Reactivité
    • 60
    • 15
    • 14
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 59
    • 1
    Lapin
    Clonalité
    • 60
    Polyclonal
    Conjugué
    • 22
    • 6
    • 5
    • 5
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Cet anticorp PTRH2 est non-conjugé
    Application
    • 41
    • 27
    • 19
    • 10
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This Bit1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 80-110 amino acids from the Central region of human Bit1.
    Clone
    RB06095
    Isotype
    Ig Fraction
    Top Product
    Discover our top product PTRH2 Anticorps primaire
  • Indications d'application
    WB: 1:1000. IHC-P: 1:10~50
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Antigène
    PTRH2 (Peptidyl-tRNA Hydrolase 2 (PTRH2))
    Autre désignation
    Bit1 (PTRH2 Produits)
    Synonymes
    anticorps BIT1, anticorps PTH2, anticorps A230072I16Rik, anticorps Bit1, anticorps CGI-147, anticorps wu:fj09f02, anticorps zgc:109954, anticorps RGD1306819, anticorps peptidyl-tRNA hydrolase 2, anticorps ptrh2, anticorps CC1G_10259, anticorps ANI_1_1036184, anticorps AOR_1_2082154, anticorps PTRH2, anticorps Ptrh2
    Sujet
    Adhesion to extracellular matrix regulates cell survival via integrin engagement and cell spreading. Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment. A role for Bit1 (Bcl-2 inhibitor of transcription 1) has been identified in this process. Bit1 is a mitochondrial protein released into the cytoplasm upon onset of apoptosis where it forms a complex with AES, a small Groucho/transducin-like enhancer of split (TLE) protein and induces caspase-independent apoptosis. AES and TLE proteins are transcriptional co-repressors that play important roles in neurogenesis, segmentation, and sex determination. Bit1-AES complexes may switch off a survival-promoting gene transcription program controlled by TLE. Apoptosis of Bit1/AES transfected cells is inhibited when cells are permitted to attach to fibronectin through the alpha-beta integrin, suggesting that the contribution of the Bit1-AES pathway to anoikis is regulated by integrins.
    Poids moléculaire
    19194
    ID gène
    51651
    NCBI Accession
    NP_057161
    UniProt
    Q9Y3E5
Vous êtes ici:
Support technique