This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This MUC20 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 61-90 amino acids from the N-terminal region of human MUC20.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Stockage commentaire
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Date de péremption
6 months
Wieben, Aleff, Eckloff, Atkinson, Baheti, Middha, Brown, Patel, Kocher, Baratz: "Comprehensive assessment of genetic variants within TCF4 in Fuchs' endothelial corneal dystrophy." dans: Investigative ophthalmology & visual science, Vol. 55, Issue 9, pp. 6101-7, (2014) (PubMed).
Woodward, Argüeso: "Expression analysis of the transmembrane mucin MUC20 in human corneal and conjunctival epithelia." dans: Investigative ophthalmology & visual science, Vol. 55, Issue 10, pp. 6132-8, (2014) (PubMed).
This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The shorter isoform expressed by this gene is localized to the plasma membrane, whereas the longer isoform might be secreted. The C terminus of this protein associates with the multifunctional docking site of the met proto-oncogene and suppresses activation of some downstream met signaling cascades. The protein features a tandem repeat domain that varies between 2 and 6 copies in different individuals. Multiple transcript variants encoding different isoforms have been found for this gene.