This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Immunogène
This CYP21A2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 216-246 amino acids from the Central region of human CYP21A2.
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Stockage commentaire
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Date de péremption
6 months
OShaughnessy, Monteiro, Bhattacharya, Fraser, Fowler: "Steroidogenic enzyme expression in the human fetal liver and potential role in the endocrinology of pregnancy." dans: Molecular human reproduction, Vol. 19, Issue 3, pp. 177-87, (2013) (PubMed).
Antigène
CYP21A2
(Cytochrome P450, Family 21, Subfamily A, Polypeptide 2 (CYP21A2))
anticorps CA21H, anticorps CAH1, anticorps CPS1, anticorps CYP21, anticorps CYP21B, anticorps P450c21B, anticorps 21-OH, anticorps 21OH, anticorps 21OHA, anticorps 21OHB, anticorps CYP21OH-A, anticorps Cyp21, anticorps Cyp21-ps1, anticorps Cyp21B, anticorps Cyp21a2-ps, anticorps Cyp21a2ps, anticorps Oh21-1, anticorps Oh21-2, anticorps CYP21A, anticorps 21-OHase, anticorps cytochrome P450 family 21 subfamily A member 2, anticorps cytochrome P450, family 21, subfamily a, polypeptide 1, anticorps cytochrome P450c21, anticorps cytochrome P450, family 21, subfamily A, polypepide 2, anticorps cytochrome P450, family 21, subfamily A, polypeptide 2, anticorps steroid 21-hydroxylase-like, anticorps CYP21A2, anticorps Cyp21a1, anticorps LOC101094596
Sujet
CYP21A2 is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates steroids at the 21 position. Its activity is required for the synthesis of steroid hormones including cortisol and aldosterone. Mutations in CYP21A2 gene cause congenital adrenal hyperplasia.