This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This GSDMB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 208-237 amino acids from the Central region of human GSDMB.
GSDMB
Reactivité: Humain
ELISA
Hôte: Lapin
Polyclonal
HRP
Indications d'application
WB: 1:1000
Restrictions
For Research Use only
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Agent conservateur
Sodium azide
Précaution d'utilisation
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Stock
4 °C,-20 °C
Stockage commentaire
Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Date de péremption
6 months
Das, Miller, Beppu, Mueller, McGeough, Vuong, Karta, Rosenthal, Chouiali, Doherty, Kurten, Hamid, Hoffman, Broide: "GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 113, Issue 46, pp. 13132-13137, (2018) (PubMed).
GSDMB is a protein with 3' exonuclease activity. Enzymes with this activity are involved in DNA replication, repair, and recombination. Similarity to an E. coli protein suggests that this enzyme may be a subunit of DNA polymerase III, which does not have intrinsic exonuclease activity.