SFRP1 anticorps (N-Term)

N° du produit ABIN652980

Détail du produit anti-SFRP1 anticorps

Antigène: SFRP1 (Secreted Frizzled-Related Protein 1 (SFRP1))

Épitope: AA 26-55, N-Term

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp SFRP1 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This SFRP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the N-terminal region of human SFRP1.

Clone: RB21557

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-SFRP1 (ABIN652980)

Zang, Zhang, Gao, Huang: "Ophiopogonin D inhibits cell proliferation, causes cell cycle arrest at G2/M, and induces apoptosis in human breast carcinoma MCF-7 cells." dans: Journal of integrative medicine, Vol. 14, Issue 1, pp. 51-9, (2016) (PubMed).

Chang, Lei, Qin, Zeng, Zhang, Jin, Wang, Wang, Su: "Expression and prognostic value of SFRP1 and β-catenin in patients with glioblastoma." dans: Oncology letters, Vol. 11, Issue 1, pp. 69-74, (2016) (PubMed).

Zhou, Chen, Mashrah, Zhu, Liu, Yang, He, Wang, Xiang, Yao, Guo, Yang, Zhang: "Deregulation of secreted frizzled-related proteins is associated with aberrant β-catenin activation in the carcinogenesis of oral submucous fibrosis." dans: OncoTargets and therapy, Vol. 8, pp. 2923-31, (2015) (PubMed).

Détails sur SFRP1

Antigène: SFRP1 (Secreted Frizzled-Related Protein 1 (SFRP1))

Autre désignation: SFRP1 (SFRP1 Produits)

Synonymes: anticorps FRP, anticorps FRP-1, anticorps FRP1, anticorps FrzA, anticorps SARP2, anticorps 2210415K03Rik, anticorps AW011917, anticorps AW107218, anticorps AW742929, anticorps sFRP-1, anticorps CSFRP1, anticorps SFRP1, anticorps XfrzA, anticorps frp, anticorps frp-1, anticorps frp1, anticorps frzA, anticorps sarp2, anticorps sfrp1, anticorps LOC100231868, anticorps Srfp1a, anticorps wu:fd19b09, anticorps secreted frizzled related protein 1, anticorps secreted frizzled-related protein 1, anticorps Secreted frizzled-related protein 1, anticorps secreted frizzled-related protein 1a, anticorps secreted frizzled-related protein 1b, anticorps SFRP1, anticorps Sfrp1, anticorps sfrp1, anticorps sfrp1a, anticorps sfrp1b

Sujet: SFRP1 encodes a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. Members of this family act as soluble modulators of Wnt signaling, epigenetic silencing of SFRP genes leads to deregulated activation of the Wnt-pathway which is associated with cancer.

Poids moléculaire: 35386

ID gène: 6422

NCBI Accession: NP_003003

UniProt: Q8N474

Pathways: Signalisation WNT, Intracellular Steroid Hormone Receptor Signaling Pathway, Negative Regulation of Hormone Secretion, Regulation of Intracellular Steroid Hormone Receptor Signaling, Stem Cell Maintenance, Tube Formation, Positive Regulation of fat Cell Differentiation