This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This CPSF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-123 amino acids from the Central region of human CPSF4.
anticorps cpsf30, anticorps nar, anticorps neb1, anticorps 30kDa, anticorps C79664, anticorps CPSF30, anticorps NAR, anticorps NEB1, anticorps cleavage and polyadenylation specific factor 4, anticorps cleavage and polyadenylation specific factor 4, 30kDa, anticorps cleavage and polyadenylation specific factor 4 S homeolog, anticorps CPSF4, anticorps Cpsf4, anticorps LOC733099, anticorps LOC100360200, anticorps cpsf4.S, anticorps cpsf4
Sujet
Inhibition of the nuclear export of poly(A)-containing mRNAs caused by the influenza A virus NS1 protein requires its effector domain. The NS1 effector domain functionally interacts with the cellular 30 kDa subunit of cleavage and polyadenylation specific factor 4, an essential component of the 3' end processing machinery of cellular pre-mRNAs. In influenza virus-infected cells, the NS1 protein is physically associated with cleavage and polyadenylation specific factor 4, 30kD subunit. Binding of the NS1 protein to the 30 kDa protein in vitro prevents CPSF binding to the RNA substrate and inhibits 3' end cleavage and polyadenylation of host pre-mRNAs. Thus the NS1 protein selectively inhibits the nuclear export of cellular, and not viral, mRNAs.