PDK2 anticorps

N° du produit ABIN653784

Détail du produit anti-PDK2 anticorps

Antigène: PDK2 (Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2))

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PDK2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This PDK2 antibody is generated from rabbits immunized with recombinant protein of human PDK2.

Clone: RB23089

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. IHC-P: 1:10~50. FC: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Références pour anticorps anti-PDK2 (ABIN653784)

Qvit, Disatnik, Sho, Mochly-Rosen: "Selective Phosphorylation Inhibitor of Delta Protein Kinase C-Pyruvate Dehydrogenase Kinase Protein-Protein Interactions: Application for Myocardial Injury in Vivo." dans: Journal of the American Chemical Society, Vol. 138, Issue 24, pp. 7626-35, (2018) (PubMed).

Qvit, Joshi, Cunningham, Ferreira, Mochly-Rosen: "Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) Protein-Protein Interaction Inhibitor Reveals a Non-catalytic Role for GAPDH Oligomerization in Cell Death." dans: The Journal of biological chemistry, Vol. 291, Issue 26, pp. 13608-21, (2016) (PubMed).

Le Page, Rider, Lewis, Ball, Clarke, Johansson, Carr, Heather, Tyler: "Increasing Pyruvate Dehydrogenase Flux as a Treatment for Diabetic Cardiomyopathy: A Combined 13C Hyperpolarized Magnetic Resonance and Echocardiography Study." dans: Diabetes, Vol. 64, Issue 8, pp. 2735-43, (2015) (PubMed).

Sun, Chang, Fu, Liu, Califano: "Chronic CSE treatment induces the growth of normal oral keratinocytes via PDK2 upregulation, increased glycolysis and HIF1? stabilization." dans: PLoS ONE, Vol. 6, Issue 1, pp. e16207, (2011) (PubMed).

Détails sur PDK2

Antigène: PDK2 (Pyruvate Dehydrogenase Kinase, Isozyme 2 (PDK2))

Autre désignation: PDK2 (PDK2 Produits)

Synonymes: anticorps PDHK2, anticorps PDKII, anticorps Pdk, anticorps zgc:56209, anticorps PDK2, anticorps pyruvate dehydrogenase kinase 2, anticorps pyruvate dehydrogenase kinase, isoenzyme 2, anticorps pyruvate dehydrogenase kinase, isozyme 2b, anticorps PDK2, anticorps Pdk2, anticorps pdk2b

Sujet: PDK2 inhibits the mitochondrial pyruvate dehydrogenase complex by phosphorylation of the E1 alpha subunit, thus contributing to the regulation of glucose metabolism.

Poids moléculaire: 46154

ID gène: 5164

NCBI Accession: NP_001186827, NP_001186828, NP_002602

UniProt: Q15119

Pathways: Signalisation PI3K-Akt, Signalisation RTK, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, L'effet Warburg