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PYM anticorps (N-Term)

WIBG Reactivité: Humain WB, IHC (p) Hôte: Lapin Polyclonal RB28144 unconjugated
N° du produit ABIN654666
  • Antigène Voir toutes PYM (WIBG) Anticorps
    PYM (WIBG) (Partner of Y14 and mago (WIBG))
    Épitope
    • 7
    • 7
    • 7
    • 2
    • 1
    • 1
    AA 12-40, N-Term
    Reactivité
    • 29
    • 19
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Humain
    Hôte
    • 27
    • 2
    Lapin
    Clonalité
    • 27
    • 2
    Polyclonal
    Conjugué
    • 12
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Cet anticorp PYM est non-conjugé
    Application
    • 21
    • 15
    • 13
    • 4
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    B, M
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This WIBG antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 12-40 amino acids from the N-terminal region of human WIBG.
    Clone
    RB28144
    Isotype
    Ig Fraction
  • Indications d'application
    WB: 1:1000. IHC-P: 1:50~100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
    Date de péremption
    6 months
  • Antigène
    PYM (WIBG) (Partner of Y14 and mago (WIBG))
    Autre désignation
    WIBG (WIBG Produits)
    Synonymes
    anticorps BEST:HL05757, anticorps CG10330, anticorps CG30176, anticorps Dmel\\CG30176, anticorps PYM, anticorps Pym, anticorps UD3, anticorps A030010B05Rik, anticorps zgc:65891, anticorps zgc:77281, anticorps Partner of Y14 and Mago, anticorps Wibg protein, anticorps PYM homolog 1, exon junction complex associated factor L homeolog, anticorps PYM homolog 1, exon junction complex associated factor, anticorps Pym, anticorps wibg, anticorps pym1.L, anticorps PYM1, anticorps Pym1, anticorps pym1
    Sujet
    Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmarks for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as a EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA, the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC.
    Poids moléculaire
    22656
    ID gène
    84305
    NCBI Accession
    NP_001137325, NP_115721
    UniProt
    Q9BRP8
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