FZD6 anticorps (AA 493-520)

N° du produit ABIN654962

Détail du produit anti-FZD6 anticorps

Antigène: FZD6 (Frizzled Family Receptor 6 (FZD6))

Épitope: AA 493-520

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp FZD6 est non-conjugé

Application: Western Blotting (WB)

Homologie: M

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This FZD6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 493-520 amino acids from the Central region of human FZD6.

Clone: RB25725

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur FZD6

Antigène: FZD6 (Frizzled Family Receptor 6 (FZD6))

Autre désignation: FZD6 (FZD6 Produits)

Synonymes: anticorps zgc:65879, anticorps zgc:77440, anticorps fz6, anticorps frz6, anticorps Xfrz6, anticorps frizzled6, anticorps frizzled-6, anticorps FZ-6, anticorps FZ6, anticorps HFZ6, anticorps NDNC10, anticorps Frizzled-6, anticorps Fz6, anticorps frizzled class receptor 6, anticorps frizzled class receptor 6 S homeolog, anticorps fzd6, anticorps fzd6.S, anticorps FZD6, anticorps Fzd6

Sujet: This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants.

Poids moléculaire: 79292

ID gène: 8323

NCBI Accession: NP_001158087, NP_001158088, NP_003497

UniProt: O60353

Pathways: Signalisation WNT, Tube Formation