ASXL1 anticorps (AA 521-549)

N° du produit ABIN655084

Détail du produit anti-ASXL1 anticorps

Antigène: ASXL1 (Additional Sex Combs Like 1 (ASXL1))

Épitope: AA 521-549

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp ASXL1 est non-conjugé

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This ASXL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 521-549 amino acids from the Central region of human ASXL1.

Clone: RB24070

Isotype: Ig Fraction

Information d'application

Indications d'application: IF: 1:10~50. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Détails sur ASXL1

Antigène: ASXL1 (Additional Sex Combs Like 1 (ASXL1))

Autre désignation: ASXL1 (ASXL1 Produits)

Synonymes: anticorps asxl1, anticorps MGC83850, anticorps mKIAA0978, anticorps BOPS, anticorps MDS, anticorps additional sex combs like 1, transcriptional regulator L homeolog, anticorps additional sex combs like 1, transcriptional regulator, anticorps additional sex combs like 1, anticorps asxl1.L, anticorps ASXL1, anticorps asxl1, anticorps Asxl1

Sujet: This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants.

Poids moléculaire: 165432

ID gène: 171023

NCBI Accession: NP_056153

UniProt: Q8IXJ9

Pathways: Retinoic Acid Receptor Signaling Pathway