This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogène
This Neuropilin-2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 798-827 amino acids from the C-terminal region of human Neuropilin-2.
Davare, Lal, Peckham, Prajapati, Gultekin, Rubin, Keller: "Secreted meningeal chemokines, but not VEGFA, modulate the migratory properties of medulloblastoma cells." dans: Biochemical and biophysical research communications, Vol. 450, Issue 1, pp. 555-60, (2014) (PubMed).
This gene encodes a member of the neuropilin family of receptor proteins. The encoded transmembrane protein binds to SEMA3C protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C} and SEMA3F protein {sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F}, and interacts with vascular endothelial growth factor (VEGF). This protein may play a role in cardiovascular development, axon guidance, and tumorigenesis. Multiple transcript variants encoding distinct isoforms have been identified for this gene.