RAD17 anticorps (AA 218-246)
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- Antigène Voir toutes RAD17 Anticorps
- RAD17
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Épitope
- AA 218-246
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Reactivité
- Humain
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp RAD17 est non-conjugé
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Application
- Western Blotting (WB), Flow Cytometry (FACS)
- Purification
- This antibody is purified through a protein A column, followed by peptide affinity purification.
- Immunogène
- This RAD17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 218-246 amino acids from the Central region of human RAD17.
- Clone
- RB20035
- Isotype
- Ig Fraction
- Top Product
- Discover our top product RAD17 Anticorps primaire
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- Indications d'application
- WB: 1:1000. FC: 1:10~50
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- 4 °C,-20 °C
- Stockage commentaire
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
- Date de péremption
- 6 months
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- Antigène
- RAD17
- Autre désignation
- RAD17 (RAD17 Produits)
- Synonymes
- anticorps zgc:91969, anticorps RAD17, anticorps K2A18.21, anticorps K2A18_21, anticorps RADIATION SENSITIVE 17, anticorps CCYC, anticorps HRAD17, anticorps R24L, anticorps RAD17SP, anticorps RAD24, anticorps 9430035O09Rik, anticorps MmRad24, anticorps RAD17 checkpoint clamp loader component, anticorps Rad17p, anticorps RADIATION SENSITIVE 17, anticorps RAD17, anticorps rad17, anticorps ATRAD17, anticorps Rad17
- Sujet
- The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.
- Poids moléculaire
- 77055
- ID gène
- 5884
- NCBI Accession
- NP_001265551, NP_002864, NP_579916, NP_579917, NP_579918, NP_579919, NP_579920, NP_579921, NP_579922
- UniProt
- O75943
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