PDP anticorps (AA 308-336)

N° du produit ABIN656386

Détail du produit anti-PDP anticorps

Antigène: PDP (Pyruvate Dehydrogenase Phosphatase (PDP))

Épitope: AA 308-336

Reactivité: Humain, Rat

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp PDP est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This PDP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 308-336 amino acids from the Central region of human PDP1.

Clone: RB31327

Isotype: Ig Fraction

Information d'application

Indications d'application: WB: 1:1000. WB: 1:2000. IHC-P: 1:10~50

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: PDP1 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Date de péremption: 6 months

Références pour anticorps anti-PDP (ABIN656386)

Shan, Kang, Elf, Xie, Gu, Aguiar, Lonning, Hitosugi, Chung, Arellano, Khoury, Shin, Khuri, Boggon, Fan: "Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth." dans: The Journal of biological chemistry, Vol. 289, Issue 31, pp. 21413-22, (2014) (PubMed).

Détails sur PDP

Antigène: PDP (Pyruvate Dehydrogenase Phosphatase (PDP))

Autre désignation: PDP1 (PDP Produits)

Synonymes: anticorps 153332_at, anticorps CG12151, anticorps Dmel\\CG12151, anticorps PDP, anticorps pdp, anticorps PDH, anticorps PDPC, anticorps PPM2C, anticorps Gm1024, anticorps Ppm2c, anticorps im:7157162, anticorps zgc:174908, anticorps pdp1, anticorps ppm2c, anticorps Pyruvate dehydrogenase phosphatase, anticorps pyruvate dehydrogenase [acetyl-transferring]-phosphatase 1, mitochondrial, anticorps pyruvate dehyrogenase phosphatase catalytic subunit 1, anticorps pyruvate dehyrogenase phosphatase catalytic subunit 1 L homeolog, anticorps Pdp, anticorps LOC413080, anticorps PDP1, anticorps Pdp1, anticorps pdp1, anticorps pdp1.L

Sujet: Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported, one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Poids moléculaire: 61054

ID gène: 54704

NCBI Accession: NP_001155251, NP_001155252, NP_001155253, NP_060914

UniProt: Q9P0J1