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PLOD1 anticorps (N-Term)

PLOD1 Reactivité: Humain WB, FACS, IHC (p) Hôte: Lapin Polyclonal RB30211 unconjugated
N° du produit ABIN656585
  • Antigène Voir toutes PLOD1 Anticorps
    PLOD1 (Procollagen-Lysine,2-Oxoglutarate 5-Dioxygenase 1 (PLOD1))
    Épitope
    • 7
    • 7
    • 7
    • 1
    • 1
    • 1
    • 1
    AA 66-94, N-Term
    Reactivité
    • 20
    • 2
    Humain
    Hôte
    • 18
    • 3
    Lapin
    Clonalité
    • 19
    • 2
    Polyclonal
    Conjugué
    • 11
    • 2
    • 2
    • 2
    • 2
    • 2
    Cet anticorp PLOD1 est non-conjugé
    Application
    • 20
    • 15
    • 13
    • 13
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Homologie
    M
    Purification
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogène
    This PLOD1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the N-terminal region of human PLOD1.
    Clone
    RB30211
    Isotype
    Ig Fraction
  • Indications d'application
    WB: 1:1000. WB: 1:1000. WB: 1:1000-1:2000. WB: 1:2000. IHC-P: 1:25. IHC-P: 1:10~50. FC: 1:25
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Agent conservateur
    Sodium azide
    Précaution d'utilisation
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Stock
    4 °C,-20 °C
    Stockage commentaire
    PLOD1 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.
    Date de péremption
    6 months
  • Lindert, Cabral, Ausavarat, Tongkobpetch, Ludin, Barnes, Yeetong, Weis, Krabichler, Srichomthong, Makareeva, Janecke, Leikin, Röthlisberger, Rohrbach, Kennerknecht, Eyre, Suphapeetiporn, Giunta et al.: "MBTPS2 mutations cause defective regulated intramembrane proteolysis in X-linked osteogenesis imperfecta. ..." dans: Nature communications, Vol. 7, pp. 11920, (2018) (PubMed).

    Cabral, Ishikawa, Garten, Makareeva, Sargent, Weis, Barnes, Webb, Shaw, Ala-Kokko, Lacbawan, Högler, Leikin, Blank, Zimmerberg, Eyre, Yamada, Marini: "Absence of the ER Cation Channel TMEM38B/TRIC-B Disrupts Intracellular Calcium Homeostasis and Dysregulates Collagen Synthesis in Recessive Osteogenesis Imperfecta." dans: PLoS genetics, Vol. 12, Issue 7, pp. e1006156, (2016) (PubMed).

    Wågsäter, Paloschi, Hanemaaijer, Hultenby, Bank, Franco-Cereceda, Lindeman, Eriksson: "Impaired collagen biosynthesis and cross-linking in aorta of patients with bicuspid aortic valve." dans: Journal of the American Heart Association, Vol. 2, Issue 1, pp. e000034, (2013) (PubMed).

  • Antigène
    PLOD1 (Procollagen-Lysine,2-Oxoglutarate 5-Dioxygenase 1 (PLOD1))
    Autre désignation
    PLOD1 (PLOD1 Produits)
    Synonymes
    anticorps EDS6, anticorps LH, anticorps LH1, anticorps LLH, anticorps PLOD, anticorps Plod, anticorps procollagen-lysine, anticorps 2410042F05Rik, anticorps AI854890, anticorps AV007929, anticorps Lh1, anticorps plod1, anticorps ik:tdsubs_rzpd609-29b19, anticorps plod, anticorps wu:fc29c10, anticorps wu:fc95g08, anticorps wu:fi18a05, anticorps zgc:152876, anticorps procollagen-lysine,2-oxoglutarate 5-dioxygenase 1, anticorps procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1, anticorps procollagen-lysine,2-oxoglutarate 5-dioxygenase 3, anticorps procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 L homeolog, anticorps procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1a, anticorps PLOD1, anticorps Plod1, anticorps PLOD3, anticorps plod1.L, anticorps plod1a
    Sujet
    Lysyl hydroxylase is a membrane-bound homodimeric protein localized to the cisternae of the endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VI have deficiencies in lysyl hydroxylase activity.
    Poids moléculaire
    83550
    ID gène
    5351
    NCBI Accession
    NP_000293
    UniProt
    Q02809
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