BCR anticorps
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- Antigène Voir toutes BCR Anticorps
- BCR (Breakpoint Cluster Region (BCR))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp BCR est non-conjugé
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Application
- Western Blotting (WB), Immunohistochemistry (IHC)
- Purification
- Affinity purification
- Immunogène
- Recombinant protein of human BCR
- Isotype
- IgG
- Top Product
- Discover our top product BCR Anticorps primaire
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- Indications d'application
- WB 1:500 - 1:2000 IHC 1:50 - 1:100
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
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- Antigène
- BCR (Breakpoint Cluster Region (BCR))
- Autre désignation
- BCR (BCR Produits)
- Synonymes
- anticorps si:dkey-83d9.7, anticorps zK83D9.7, anticorps BCR, anticorps ALL, anticorps BCR1, anticorps CML, anticorps D22S11, anticorps D22S662, anticorps PHL, anticorps 5133400C09Rik, anticorps AI561783, anticorps AI853148, anticorps mKIAA3017, anticorps breakpoint cluster region, anticorps BCR, RhoGEF and GTPase activating protein, anticorps bcr, anticorps BCR, anticorps Bcr
- Sujet
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Synonyms: ALL,bcr,BCR/ABL FUSION GENE,INCLUDED,BCR/FGFR1 chimera protein,BCR/FGFR1 FUSION GENE,INCLUDED,BCR/PDGFRA FUSION GENE,INCLUDED,BCR,BCR1,Breakpoint cluster region,Breakpoint cluster region protein,CML,D22S11,D22S662,FGFR1/BCR chimera protein,PHL,Renal carcinoma antigen NY-REN-26
Background: A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene.
- Poids moléculaire
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Observed_MW: 150kDa
Calculated_MW: 137kDa/142kDa
- ID gène
- 613
- UniProt
- P11274
- Pathways
- Regulation of Leukocyte Mediated Immunity, Platelet-derived growth Factor Receptor Signaling
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