KIR2DL3 anticorps
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- Antigène Voir toutes KIR2DL3 Anticorps
- KIR2DL3 (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 3 (KIR2DL3))
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp KIR2DL3 est non-conjugé
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Application
- Western Blotting (WB), Immunofluorescence (IF)
- Purification
- Affinity purification
- Immunogène
- Recombinant fusion protein of human KIR2DL3 (NP_056952.2).
- Isotype
- IgG
- Top Product
- Discover our top product KIR2DL3 Anticorps primaire
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- Indications d'application
- WB 1:500-1:2000 IF 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
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- Antigène
- KIR2DL3 (Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 3 (KIR2DL3))
- Autre désignation
- KIR2DL3 (KIR2DL3 Produits)
- Synonymes
- anticorps CD158B2, anticorps CD158b, anticorps GL183, anticorps KIR-023GB, anticorps KIR-K7b, anticorps KIR-K7c, anticorps KIRCL23, anticorps NKAT, anticorps NKAT2, anticorps NKAT2A, anticorps NKAT2B, anticorps p58, anticorps killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 3, anticorps KIR2DL3
- Sujet
- Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules, thus, KIR proteins are thought to play an important role in regulation of the immune response.
- Poids moléculaire
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Observed_MW: 45kDa
Calculated_MW: 27kDa/37kDa
- ID gène
- 3804
- UniProt
- P43628
- Pathways
- Cancer Immune Checkpoints
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