IKZF1 anticorps
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- Antigène Voir toutes IKZF1 Anticorps
- IKZF1 (IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))
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Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp IKZF1 est non-conjugé
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Application
- Immunofluorescence (IF)
- Purification
- Affinity purification
- Immunogène
- Recombinant fusion protein of human IKZF1 (NP_001207694.1).
- Isotype
- IgG
- Top Product
- Discover our top product IKZF1 Anticorps primaire
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- Indications d'application
- IF 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
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- Antigène
- IKZF1 (IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))
- Autre désignation
- IKZF1 (IKZF1 Produits)
- Synonymes
- anticorps Hs.54452, anticorps IK1, anticorps IKAROS, anticorps LYF1, anticorps PRO0758, anticorps ZNFN1A1, anticorps hIk-1, anticorps RGD1562979, anticorps ikaros, anticorps znfn1a1, anticorps ik1, anticorps lyf1, anticorps hik-1, anticorps pro0758, anticorps hs.54452, anticorps MGC108252, anticorps 5832432G11Rik, anticorps Ikaros, anticorps LyF-1, anticorps Zfpn1a1, anticorps Znfn1a1, anticorps hlk-1, anticorps mKIAA4227, anticorps ikzf1, anticorps IKAROS family zinc finger 1, anticorps IKAROS family zinc finger 1 (Ikaros), anticorps IKZF1, anticorps Ikzf1, anticorps ikzf1
- Sujet
- This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).
- Poids moléculaire
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Observed_MW: 46kDa
Calculated_MW: 24-31kDa/41-57kDa
- ID gène
- 10320
- UniProt
- Q13422
- Pathways
- Production of Molecular Mediator of Immune Response
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