IL12RB1 anticorps
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- Antigène Voir toutes IL12RB1 Anticorps
- IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp IL12RB1 est non-conjugé
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Application
- Immunofluorescence (IF)
- Purification
- Affinity purification
- Immunogène
- Recombinant fusion protein of human IL12RB1 (NP_714912.1).
- Isotype
- IgG
- Top Product
- Discover our top product IL12RB1 Anticorps primaire
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- Indications d'application
- IF 1:10-1:100
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
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- Antigène
- IL12RB1 (Interleukin 12 Receptor beta 1 (IL12RB1))
- Autre désignation
- IL12RB1 (IL12RB1 Produits)
- Synonymes
- anticorps Il12rb, anticorps IL12RB1, anticorps IL-12R, anticorps CD212, anticorps IL-12R-BETA1, anticorps IL12RB, anticorps IL-12R[b], anticorps interleukin 12 receptor subunit beta 1, anticorps interleukin 12 receptor, beta 1, anticorps Il12rb1, anticorps IL12RB1
- Sujet
- The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants.
- Poids moléculaire
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Observed_MW: 73kDa
Calculated_MW: 42kDa/72kDa/73kDa
- ID gène
- 3594
- UniProt
- P42701
- Pathways
- Signalistation JAK/STAT, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation
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