HYOU1 anticorps
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- Antigène Voir toutes HYOU1 Anticorps
- HYOU1 (Hypoxia Up Regulated 1 (HYOU1))
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Reactivité
- Humain, Souris
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp HYOU1 est non-conjugé
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Application
- Immunohistochemistry (IHC)
- Purification
- Affinity purification
- Immunogène
- Recombinant fusion protein of human HYOU1 (NP_001124463.1).
- Isotype
- IgG
- Top Product
- Discover our top product HYOU1 Anticorps primaire
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- Indications d'application
- IHC 1:50-1:200
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
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- Antigène
- HYOU1 (Hypoxia Up Regulated 1 (HYOU1))
- Autre désignation
- HYOU1 (HYOU1 Produits)
- Synonymes
- anticorps GRP-170, anticorps Grp170, anticorps HSP12A, anticorps ORP-150, anticorps ORP150, anticorps AI415631, anticorps CBP-140, anticorps Cab140, anticorps Orp150, anticorps id:ibd5056, anticorps wu:fd14c05, anticorps zgc:56019, anticorps HYOU1, anticorps orp150, anticorps GRP170, anticorps hypoxia up-regulated 1, anticorps hypoxia up-regulated protein 1, anticorps hypoxia up-regulated 1 S homeolog, anticorps HYOU1, anticorps Hyou1, anticorps hyou1, anticorps LOC100380749, anticorps hyou1.S
- Sujet
- The protein encoded by this gene belongs to the heat shock protein 70 family. This gene uses alternative transcription start sites. A cis-acting segment found in the 5' UTR is involved in stress-dependent induction, resulting in the accumulation of this protein in the endoplasmic reticulum (ER) under hypoxic conditions. The protein encoded by this gene is thought to play an important role in protein folding and secretion in the ER. Since suppression of the protein is associated with accelerated apoptosis, it is also suggested to have an important cytoprotective role in hypoxia-induced cellular perturbation. This protein has been shown to be up-regulated in tumors, especially in breast tumors, and thus it is associated with tumor invasiveness. This gene also has an alternative translation initiation site, resulting in a protein that lacks the N-terminal signal peptide. This signal peptide-lacking protein, which is only 3 amino acids shorter than the mature protein in the ER, is thought to have a housekeeping function in the cytosol. In rat, this protein localizes to both the ER by a carboxy-terminal peptide sequence and to mitochondria by an amino-terminal targeting signal. Alternative splicing results in multiple transcript variants.
- Poids moléculaire
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Observed_MW: 150kDa
Calculated_MW: 62kDa/111kDa
- ID gène
- 10525
- UniProt
- Q9Y4L1
- Pathways
- ER-Nucleus Signaling, SARS-CoV-2 Protein Interactome
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