FGD4 anticorps
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- Antigène Voir toutes FGD4 Anticorps
- FGD4 (FYVE, RhoGEF and PH Domain Containing 4 (FGD4))
- Reactivité
- Humain, Souris, Rat
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Hôte
- Lapin
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Clonalité
- Polyclonal
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Conjugué
- Cet anticorp FGD4 est non-conjugé
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Application
- Western Blotting (WB)
- Purification
- Affinity purification
- Immunogène
- Recombinant protein of human FGD4
- Isotype
- IgG
- Top Product
- Discover our top product FGD4 Anticorps primaire
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- Indications d'application
- WB 1:500 - 1:2000
- Restrictions
- For Research Use only
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- Concentration
- 1 mg/mL
- Buffer
- Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- Agent conservateur
- Sodium azide
- Précaution d'utilisation
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Stock
- -20 °C
- Stockage commentaire
- Store at -20°C. Avoid freeze / thaw cycles.
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- Antigène
- FGD4 (FYVE, RhoGEF and PH Domain Containing 4 (FGD4))
- Autre désignation
- FGD4 (FGD4 Produits)
- Sujet
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Synonyms: 9030023J02Rik,9330209B17Rik,Actin filament binding protein frabin,Actin filament-binding protein frabin,CMT4H,DKFZp313E1818,DKFZp434K1572,FGD1 related F actin binding protein,FGD1-related F-actin-binding protein,Fgd4,FGD4,FLJ34370,FLJ42663,FRABP,FYVE,FYVE, RhoGEF and PH domain containing 4,MGC57222,RhoGEF and PH domain-containing protein 4,ZFYVE6,Zinc finger FYVE domain containing protein 6,Zinc finger FYVE domain-containing protein 6
Background: This gene encodes a protein that is involved in the regulation of the actin cytoskeleton and cell shape. This protein contains an actin filament-binding domain, which together with its Dbl homology domain and one of its pleckstrin homology domains, can form microspikes. This protein can activate MAPK8 independently of the actin filament-binding domain, and it is also involved in the activation of CDC42 via the exchange of bound GDP for free GTP. The activation of CDC42 also enables this protein to play a role in mediating the cellular invasion of Cryptosporidium parvum, an intracellular parasite that infects the gastrointestinal tract. Mutations in this gene can cause Charcot-Marie-Tooth disease type 4H (CMT4H), a disorder of the peripheral nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- Poids moléculaire
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Observed_MW: 100kDa
Calculated_MW: 20kDa/32kDa/86kDa
- ID gène
- 121512
- UniProt
- Q96M96
- Pathways
- Neurotrophin Signaling Pathway
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